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Method to remove residual pesticide procymidone from ginseng extract

A technology for ginseng extraction and pesticide residues, which is used in pharmaceutical formulations, plant raw materials, and medical preparations containing active ingredients, etc., can solve the problems of large equipment investment, high operating pressure, and high pesticide residues, and achieves good removal effect and recovery. High rate and low cost effect

Active Publication Date: 2014-06-04
NINGBO LIWAH PLANT EXTRACTION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the growth cycle of ginseng is longer, and ginseng has a larger specific surface area in direct contact with the soil, so the amount of pesticide residues in it is higher, and ginseng extract is a product after further concentration, and the amount of pesticide residues in it is higher
[0004] Chinese patents 00134340.8 and 200510014554.8 respectively disclose CO 2 It is a method of purifying and removing residual pesticides in ginseng as a solvent, water, ethanol, etc. as entraining agents. These methods have a certain effect on removing organochlorine pesticides in ginseng, but there are high operating pressures, large equipment investment, and operational problems. Disadvantages such as high cost, and because ginsenoside is easily soluble in ethanol, using ethanol as entrainer will cause unnecessary loss of ginsenoside
Chinese patent 200710122559.1 discloses a method for purifying and removing residual pesticides in ginseng using propane as a solvent. Although the effect of removing residual pesticides is remarkable, propane is a flammable and explosive gas, which requires high explosion-proof equipment and operation.

Method used

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  • Method to remove residual pesticide procymidone from ginseng extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 50g ginseng extract sample (purchased from Ningbo Jinai Nong Biotechnology Co., Ltd.), dissolve it in 45°C water with 3 times the volume (v / m), let it stand for 0.5-1 hour, let it cool, add mixed solvent A for extraction , the amount of mixed solvent for each extraction is 1 / 3~1 of the solution volume, a total of 5 extractions, and each extraction is left to stand for 60 minutes. After the extraction is completed, the lower aqueous solution is concentrated to a specific gravity of 1.2 (measured by a Bomer meter), and placed at 70 ° C. Dry in a vacuum oven for 4 hours, pulverize, and pass through a 120-mesh sieve to obtain the finished product.

[0022] The mixed solvent A is a mixed solvent of n-hexane, ethyl acetate and acetone, and its mixing volume ratio is n-hexane:ethyl acetate:acetone=8:2:0.5 (v / v / v).

Embodiment 2

[0024] Take 50g of ginseng extract sample, dissolve it in warm water at 40°C with 6 times the volume (v / m), let it stand for 0.5-1 hour, let it cool down, add mixed solvent A for extraction, the amount of mixed solvent added for each extraction is 1 / 2 of the volume of the solution 1 / 3 to 1, a total of 5 extractions, and each extraction was left standing for 50 minutes. After the extraction was completed, the lower aqueous solution was concentrated to a specific gravity of 1.2 (measured by a Bommer meter), dried in a vacuum oven at 70°C for 4 hours, crushed, and passed through 120 Mesh sieve to get the finished product.

[0025] The mixed solvent A is a mixed solvent of n-hexane, ethyl acetate and acetone, and its mixing volume ratio is n-hexane:ethyl acetate:acetone=6:4:1 (v / v / v).

Embodiment 3

[0027] Take 50g of ginseng extract sample, dissolve it in 80℃ warm water with 7 times the volume (v / m), let it stand for 0.5-1 hour, let it cool down, add mixed solvent A for extraction, the amount of mixed solvent added for each extraction is 1 / 2 of the solution volume 1 / 3~1, a total of 5 extractions, and each extraction was left standing for 30 minutes. After the extraction was completed, the lower aqueous solution was concentrated to a specific gravity of 1.2 (measured by a Bommer meter), dried in a vacuum oven at 70°C for 4 hours, crushed, and passed through 120 Mesh sieve to get the finished product.

[0028] The mixed solvent A is a mixed solvent of n-hexane, ethyl acetate and acetone, and its mixing volume ratio is n-hexane:ethyl acetate:acetone=7:3:0.5 (v / v / v).

[0029] Determination of the content of procymidone in the ginseng extract before and after removal in Example 1-3. Calculate removal rate and product recovery. (Product recovery rate = sample weight of ginse...

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Abstract

The invention discloses a method to remove residual pesticide procymidone from a ginseng extract. The method comprises the following steps: weighing a certain amount of a ginseng extract sample and dissolving the sample by 3-7 times amount of water at 40-80 DEG C; standing for 0.5 to 1 hour to become cold; adding 1 / 3-1 time amount of a mixture solvent A for each-time extraction to perform the extraction for five times, and respectively standing each-time extraction solution for 30-60 minutes; concentrating the lower layer aqueous solution to achieve the specific gravity of 1.2, drying the concentration solution for 4 hours in a vacuum drying oven at 70 DEG C, crushing and screening the the resultants through a 120 mesh sieve, so as to get the finished product, wherein the mixture solvent A comprises hexane, ethyl acetate and acetone, and the mixing volume ratio of hexane: ethyl acetate: acetone is 8:2:0.5 to 6:4:1. The method used for removing the residual pesticide procymidone from the ginseng extract has good removal effect, low cost and the recovery rate being over 89%.

Description

technical field [0001] The invention relates to the technical field of removing residual chemical components in plant extracts, in particular to a method for removing residual pesticide procymidone in ginseng extracts. Background technique [0002] Ginseng Panax ginseng can effectively regulate the hematopoietic function of the central nervous system, improve the contractility and frequency of the heart, lower blood sugar, and improve human immunity. [0003] However, the growth cycle of ginseng is longer, and ginseng has a larger specific surface area in direct contact with the soil, so the pesticide residues are higher, and the ginseng extract is a further concentrated product, and the pesticide residues are higher. [0004] Chinese patents 00134340.8 and 200510014554.8 respectively disclose CO 2 It is a method of purifying and removing residual pesticides in ginseng as a solvent, water, ethanol, etc. as entraining agents. These methods have a certain effect on removing o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61K125/00
CPCA61K36/258
Inventor 汪俊蒋富强斯聪聪孙振蛟程国才王财林
Owner NINGBO LIWAH PLANT EXTRACTION TECH
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