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A compound preparation for treating primary osteoporosis and its preparation method

A technology for osteoporosis and compound preparations, applied to medical preparations containing active ingredients, bone diseases, pharmaceutical formulas, etc., can solve problems such as inconvenience, mildew and deterioration of patients

Active Publication Date: 2015-10-21
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been a large number of clinical reports, and the treatment of osteoporosis with Zuogui pills has achieved good curative effect, but there are still the following deficiencies in medical practice: the curative effect needs to be consolidated, the recurrence should be reduced as much as possible, and the traditional Chinese medicine decoction needs to be decocted temporarily before taking it. , long-term home is easy to mildew and deterioration and inconvenience to patients, etc.

Method used

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  • A compound preparation for treating primary osteoporosis and its preparation method
  • A compound preparation for treating primary osteoporosis and its preparation method
  • A compound preparation for treating primary osteoporosis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take the following raw materials in parts by weight: wolfberry 30-20, cornus 30-20, yam 30-20, dodder 30-20, antler glue 30-20, tortoise shell glue 30-20, Dashudi 45-30 , Ligustrum lucidum 45~30, Shouwu 45~30, soaked for 1h, decocted 1~3 times, each time decocted for 0.5~1.5h, one decoction add 10-14 times water, the second and third decoction add water amount 6~ 10 times, combine the decoction liquor, filter, and concentrate the filtrate to an extract with a relative density of 1.05~1.30 at a temperature of 60~70℃;

[0040] ②Add ethanol to the above-mentioned extract of ① until the ethanol concentration is 50% to 80%, and let it stand overnight for alcohol precipitation. After filtering, the filtrate will recover ethanol at a temperature of 60~70℃ and concentrate to a concentrated extract with a relative density of 1.35~1.40;

[0041] ③The above-mentioned ②concentrated extract is dried under reduced pressure at 70~80℃, crushed into fine powder, and passed through a 60-mesh...

Embodiment 2

[0044] Take the following parts by weight to mix the raw materials: medlar 25-15, cornus 25-15, yam 25-15, dodder 25-15, antler gum 25-15, tortoise gum 25-15, and Dashudi 38-22 , Ligustrum 38-22, Shouwu 38-22. Soak for 1h, decoct 2 times, 1h each time, add 14 times water for one decoction, 10 times water for the second decoction, combine the decoction, filter, and concentrate the filtrate to an extract with a relative density of 1.05~1.07 ;

[0045] ②Add ethanol to the above ①extract solution to an ethanol concentration of 60%; let it stand overnight and then precipitate with alcohol. After filtering, the filtrate will recover ethanol at a temperature of 60~70℃ and concentrate to a concentrated extract with a relative density of 1.35~1.40;

[0046] ③The above-mentioned ②concentrated extract is dried under reduced pressure at 70~80℃, crushed into fine powder, and passed through a 60-mesh sieve to obtain the extract powder of the drug component;

[0047] ④According to: extract powde...

Embodiment 3

[0049] Take the following parts by weight to mix the raw materials: medlar 20-10, cornus 20-10, yam 20-10, dodder 20-10, antler gum 20-10, tortoise shell glue 20-10, and large cooked rehmannia 30-15 , Ligustrum lucidum 30-15, Shouwu 30-15, soaked for 1h, decocted twice, decocted for 1h each time, add water 14 times for one decoction, add water 10 times for the second decoction, combine the decoction liquid, filter, The filtrate is concentrated to an extract liquid with a relative density of 1.05~1.07;

[0050] ②Add ethanol to the above ①extract solution to an ethanol concentration of 60%; let it stand overnight and then precipitate with alcohol. After filtering, the filtrate will recover ethanol at a temperature of 60~70℃ and concentrate to a concentrated extract with a relative density of 1.35~1.40;

[0051] ③The above-mentioned ②concentrated extract is dried under reduced pressure at 70~80℃, crushed into fine powder, and passed through a 60-mesh sieve to obtain the extract powde...

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Abstract

The invention belongs to the traditional Chinese medicine field, and relates to a traditional Chinese medicine preparation for treating primary osteoporosis and a preparation method. The compound preparation follows a therapeutic principle of nourishing kidney yin, and employs water extracts of wolfberry, cornus officinalis, Chinese yam, semen cuscutae, deerhorn glue, glue of tortoise plastron, big rehmanniae vaporata, ligustrum lucidum and by mixing with an auxiliary material, the above materials are pelletized and performed with tabletting to prepare the compound preparation. The result of the animal experiments shows that the compound preparation bone resorption and bone formation with high level due to ovariectomy can be reduced, a balance state that the bone formation is greater than the bone resorption can be recovered, and the bone mass is increased; osteocalcin secretion can be promoted, so that the lipoblast differentiation capability can be inhibited. The compound preparation can improve the symptom of primary osteoporosis, reduce recurrence and consolidate curative effect; and can avoid the inconvenience of temporary decoction and easy deterioration for long-term placing before administration of a traditional Chinese medicine decoction for the patients.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine, and specifically relates to a compound preparation for treating primary osteoporosis and a preparation method. Background technique [0002] The prior art discloses that osteoporosis (Osteoporosis, OP) is a systemic bone disease in which bone mass decreases and bone fragility increases, leading to fractures. At present, there is no ideal therapeutic drug in clinical practice. Although hormone replacement drugs can achieve certain therapeutic effects, they also have many side effects. In recent years, studies have found that traditional Chinese medicine has certain advantages in the treatment of osteoporosis. [0003] Traditional Chinese medicine classifies osteoporosis into the categories of "osteomy" and "gubi", and believes that kidney deficiency is the root cause of osteoporosis. The use of kidney-tonifying therapy will achieve better clinical treatment results. [0004] Zuogui pill comes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P19/10A61K35/32A61K35/586
Inventor 王拥军杨铸卞琴徐浩杨洲唐德志杨锋赵永见刘书芬施杞贾友冀李晓锋王洪伸
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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