Preparation method of rebamipide eutectic
A technology of rebamipide and constant temperature cultivation, applied in the field of preparation of rebamipide co-crystals
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Embodiment 1～3
[0043] Embodiments 1-3: Preparation of rebamipide / sodium ion ethanol co-crystal
[0044] Add rebamipide, absolute ethanol and saturated aqueous sodium hydroxide solution into the autoclave, seal the autoclave and place it in a programmed temperature-controlled oven, cultivate for 3 to 5 days, pour out the liquid in the autoclave, and the solvent will naturally Obtain rebamipide / sodium ion ethanol cocrystal after volatilization;
[0045] Among them, the mass of rebamipide (mg): the volume of absolute ethanol (ml): the volume of saturated sodium hydroxide aqueous solution (ml)=35~75:10~15:1~2.
[0046] The cultivation process includes a uniform temperature rise stage from room temperature to constant temperature culture temperature, a constant temperature culture stage and a uniform temperature drop stage from constant temperature culture temperature to room temperature; the uniform temperature rise stage is 1 to 3 hours, and the uniform temperature drop stage is 7 to 10 hours. ...
Embodiment 4～6
[0049] Embodiments 4-6: Preparation of rebamipide / pentaerythritol co-crystal
[0050] Add rebamipide, pentaerythritol and absolute ethanol into the autoclave, seal the autoclave and place it in a programmed temperature-controlled oven, cultivate it for 3 to 5 days, pour out the liquid in the autoclave, and obtain Rebamipide after the solvent evaporates naturally. Bappet / Pentaerythritol co-crystal;
[0051] Among them, the mass (mg) of rebamipide: the volume (ml) of absolute ethanol: the mass (mg) of pentaerythritol=45~75:10~15:3.5~7.
[0052] The cultivation process includes a uniform temperature rise stage from room temperature to constant temperature culture temperature, a constant temperature culture stage and a uniform temperature drop stage from constant temperature culture temperature to room temperature; the uniform temperature rise stage is 1 to 3 hours, and the uniform temperature drop stage is 7 to 10 hours. The rest of the time is the stage of constant temperature cu...
Embodiment 7～9
[0054] Examples 7-9: Preparation of rebamipide / rebamipide co-crystal
[0055] Add rebamipide, absolute ethanol and distilled water into the autoclave, seal the autoclave and place it in a programmed temperature-controlled oven, cultivate it for 2 to 5 days, pour out the liquid in the autoclave, and obtain rebamipide after the solvent evaporates naturally. Bamipide / Rebamipide eutectic;
[0056] Among them, the mass of rebamipide (mg): the volume of absolute ethanol (ml): the volume of distilled water (ml) = 35-65: 10-15: 3.5-8.
[0057] The cultivation process includes a uniform temperature rise stage from room temperature to constant temperature culture temperature, a constant temperature culture stage and a uniform temperature drop stage from constant temperature culture temperature to room temperature; the uniform temperature rise stage is 1 to 3 hours, and the uniform temperature drop stage is 7 to 10 hours. The rest of the time is the stage of constant temperature cultiva...
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