Method for preparing colored empty capsules by employing natural colorants

A technology of natural colorants and hollow capsules, which can be used in capsule delivery, medical preparations with non-active ingredients, pharmaceutical formulations, etc. problem, to achieve the effect of good anti-oxidation and pH value stability, no harmful substance residues, and reducing harmful residues

Inactive Publication Date: 2013-10-02
SHAOXING KANGKE CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of science, people's health awareness is enhanced, and consumers pay more and more attention to harmful residues. Because traditional synthetic colorants participate in human metabolism, harmful residues cause hidden dangers to human health.
In recent years, relevant experts have called for restrictions and bans on the application of synthetic colorants. Synthetic colorants have poor oxidation resistance, are prone to discoloration when exposed to light and moisture, and have poor stability due to changes in pH. Problems such as dispersion, especially minerals have not been applied in the field of capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the preparation of scarlet gelatin hollow capsule

[0018] According to the mass ratio, take 40% natural coloring agent (in this embodiment, natural coloring agent is iron oxide red), 2% suspending agent (in this embodiment, suspending agent is gelatin), 0.3% dispersing agent, the rest It is water, and the above-mentioned substances are heated, stirred, dissolved and filtered to obtain the mother liquor of natural colorant; the mother liquor of natural colorant is added to the medicinal gelatin solution according to the ratio of 1-5%, and the gelatin hollow capsules made are vermilion, Consistent color, light resistance, strong oxidation resistance, and small harmful residues.

Embodiment 2

[0019] Embodiment 2: the preparation of Swiss orange hypromellose hollow capsule

[0020] According to the mass ratio, take 35% natural coloring agent (in this embodiment, the natural coloring agent is red iron oxide, iron oxide yellow is mixed according to the chromatographic ratio), 1% suspending agent (in this embodiment, the suspending agent is selected from hydroxyl propyl methylcellulose) and 0.2% dispersant, and the rest is water. After the above-mentioned substances are heated, stirred, dissolved, and filtered, a natural colorant mother liquor is obtained; the obtained natural colorant mother liquor is then added with hydroxyl In the propyl methylcellulose solution, the prepared hypromellose hollow capsules are Swiss orange, and the obtained product has the same color, light resistance, strong oxidation resistance, and small harmful residues.

Embodiment 3

[0021] Example 3: Preparation of Lake Blue Pullulan Empty Capsules

[0022] According to the mass ratio, take by weighing 30% natural coloring agent (in this embodiment, natural coloring agent selects iron oxide blue), 1% suspending agent (in this embodiment, suspending agent selects pullulan for use) and 0.2% dispersing agent, The rest is water. After heating, stirring, dissolving and filtering, the natural colorant mother liquor is obtained; the obtained natural colorant mother liquor is then added to the pullulan solution at a ratio of 1-3% to make the pullulan hollow The capsules are lake blue, and the resulting capsules have the same color, light resistance, strong oxidation resistance, and small harmful residues.

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PUM

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Abstract

The invention provides a method for preparing colored empty capsules by employing natural colorants, and belongs to the technical field of preparation of empty capsules. The natural colorants mainly comprise natural mineral colorants and plant extract colorants. Colored gelatin empty capsules, enteric gelatin empty capsules, hydroxypropyl methylcellulose empty capsules, enteric hydroxypropyl methylcellulose empty capsules, pullulan polyose empty capsules, enteric pullulan polyose empty capsules, sodium alginate empty capsules and modified starch empty capsules are prepared by the method, and oxidation resistance and light resistance of various empty capsules are raised and the color of the capsules is stabilized and not easy to fade. The empty capsules can tolerate changes in pH and have high stability. Residual of harmful substances is reduced and the products are more stable, safer and healthier.

Description

technical field [0001] The invention relates to a method for preparing colored hollow capsules by using natural colorants, and belongs to the technical field of hollow capsule preparation. Background technique [0002] Traditional empty capsule coloring has always used synthetic colorants. Because synthetic colorants have a complete spectrum, bright colors, and are easy to use, they have been used by most capsule companies until now. With the development of science, people's health awareness is enhanced, and consumers pay more and more attention to harmful residues. Because traditional synthetic colorants participate in human metabolism, harmful residues cause hidden dangers to human health. In recent years, relevant experts have called for restrictions and bans on the application of synthetic colorants. Synthetic colorants have poor oxidation resistance, are prone to discoloration when exposed to light and moisture, and have poor stability due to changes in pH. Problems su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/02A61K47/42A61K47/38A61K47/36
Inventor 俞愈潘强明
Owner SHAOXING KANGKE CAPSULE
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