Benzyloxypyrimidine derivative, agricultural/horticultural insecticide comprising derivative and method for using same
A technology of benzyloxypyrimidine and derivatives, applied in the field of agricultural and horticultural pesticides, can solve problems such as undisclosed
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Embodiment 1
[0481] Preparation of 4-(4-tert-butylbenzyloxy)-5-methoxypyrimidine (Compound No. 1-1)
[0482]
[0483] At 0°C, add 4-chloro-5-methoxypyrimidine (1.5 g, 10.3 mmol) and 4-tert-butylbenzyl alcohol (2.55 g, 15.6 mmol) described in Journal of the Chemical Society (1960), 4590 ) in dimethylacetamide (10 mL) was added sodium hydride (0.625 g, 15.6 mmol), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into ice water, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain 4-(4-tert-butylbenzyloxy)-5-methoxypyrimidine (2.16 g).
[0484] Yield: 77%
[0485] Properties: Melting point 58-59℃.
Embodiment 2
[0487] Preparation of 4-(4-trifluoromethylbenzyloxy)-5-phenoxypyrimidine (Compound No. 1-95)
[0488]
[0489] 4-Chloro-5-phenoxypyrimidine (0.4 g, 1.9 mmol) and 4-trifluoromethylbenzyl alcohol (0.36 g, 2.0 mmol) described in JP-A-49-92080 were dissolved in di To a solution in methylacetamide (7 m) was added sodium hydride (0.093 g, 2.3 mmol), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into ice water, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 4-(4-trifluoromethylbenzyloxy)-5-phenoxypyrimidine (0.60 g).
[0490] Yield: 85%
[0491] Melting point: 56-57°C.
[0492]Typical formulation examples and experimental examples of the present invention are shown below, but they should not be construed as limiting the scope of the present invention.
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preparation Embodiment 1
[0495] Compound of the present invention 10 parts
[0496] Xylene 70 parts
[0497] 10 parts of N-methylpyrrolidone
[0498] Mixture of polyoxyethylene nonylphenyl ether and calcium alkylbenzenesulfonate 10 parts
[0499] An emulsifiable cream is prepared by mixing the above ingredients well to achieve dissolution.
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