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pH sensor integration to single use bioreactor/mixer

A bioreactor container, bioreaction technology, applied in specific-purpose bioreactor/fermenter, bioreactor/fermenter combination, biochemical instruments, etc., can solve problems such as affecting the service life of sensors

Active Publication Date: 2013-10-02
ROSEMOUNT INC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Exposure to high temperatures, steam and rapid thermal shock can seriously affect sensor life

Method used

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  • pH sensor integration to single use bioreactor/mixer
  • pH sensor integration to single use bioreactor/mixer
  • pH sensor integration to single use bioreactor/mixer

Examples

Experimental program
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Embodiment Construction

[0018] It is believed that there is a need for a disposable pH sensor compatible with plastic bag type, ready to use, disposable bioreactors. Many pH sensors based on glass electrodes require protection of the sensor's reactive surface or membrane from physical or environmental damage. This function is usually provided by a disposable "shield" or cap that covers the sensing end of the sensor.

[0019] Embodiments of the present invention generally include a pH sensor mounted to the wall of a single-purpose bioreactor / mixer, wherein the bioreactor / mixer has a bacteria (gamma ray irradiation), mechanical structures that allow protective solutions to be stored around the pH sensing and reference elements during storage and transport. The mechanism also allows the storage cavity holding the protective solution to be opened to expose the detection and reference elements prior to manipulation.

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Abstract

A pH sensing bioreaction system is provided. The system includes a bioreaction container (51) having a plastic wall (50) and a pH sensor (40, 60, 80, 100, 120) attached to the plastic wall (50). The pH sensor (40, 60, 80, 100, 120) includes a sensor body (82) having a flange (76) that is sealingly attached to the plastic wall (50). The sensor body (82) has a reference electrolyte (142) therein and a first sensing element (152) disposed in the reference electrolyte (142). The first sensing element (152) is configured to contact both the reference electrolyte (142) and a sample solution (52) inside the bioreaction container. A second sensing element (62, 92, 148) is positionable into an interior of the bioreaction container (51). The pH sensor (40, 60, 80, 100, 120) has a plurality of configurations that include a booted configuration in which at least one sensing element is isolated from the interior of the bioreaction container (51), and a service configuration in which the at least one sensing element is fluidically coupled to the interior of the bioreaction container (51).

Description

Background technique [0001] pH determination is one of the most common process chemical measurements performed today. The pH value is expressed as a measure of the relative amounts of hydrogen ions and hydroxide ions in an aqueous solution. In fermentation and cell culture, one of the toughest procedural challenges is maintaining ideal pH levels. Fermentation processes use living organisms, such as yeast, bacterial, or fungal strains, to produce active ingredients. The fermentation process usually has a relatively short duration (2-7 days). Cell culture is the process by which mammalian cells are grown to produce active ingredients. The cell culture process usually takes longer (2-8 weeks). [0002] An important challenge for pH determination in the field of fermentation and cell culture involves the cleaning process of the fermenter or bioreactor. In particular, fermenters or bioreactors must be sterilized before commencing the corresponding procedures to ensure avoiding...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34
CPCC12M23/14C12M41/26C12M41/32C12M41/34
Inventor 冯昌东贝利·W·本顿戴夫·安德森杨时风韦恩·B·伍德
Owner ROSEMOUNT INC
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