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Production technology of medical sodium alginate

A technology of sodium alginate and its production method, which is applied in the field of medicinal sodium alginate, can solve the problems of difficult control of microorganisms, high inorganic impurities in products, dark color, etc., and achieve the advantages of crystallization, simple production and operation, and reduction of impurity content Effect

Active Publication Date: 2014-07-23
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] What the present invention aims to solve is the technical problem of high inorganic impurities, darker color and difficult microbial control in the existing sodium alginate production process, and to provide a method that can improve the quality of sodium alginate and is suitable for large-scale industrial production. The production method of medicinal sodium alginate, and the obtained medicinal sodium alginate meets the requirements of various indicators stipulated in the Pharmacopoeia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve 1 kg of food-grade sodium alginate in 2.5 times purified water, add 20 g of 2% peracetic acid aqueous solution and stir for 3 hours, add 0.5 kg of acetic acid, and stir thoroughly for 1 hour. Dissolve in 2.5 times purified water, add 0.1kg of anhydrous sodium carbonate, stir for 2 hours, add 1L of isopropanol, stir evenly, let stand for 2 hours, centrifuge, and dry at 60°C for 3 hours. The produced medicinal sodium alginate is a white powder. According to the 2010 edition of the Chinese Pharmacopoeia, its chloride content is not more than 0.1%. The microorganisms meet the requirements of the Pharmacopoeia and meet the requirements for medicinal use. The obtained medicinal sodium alginate was 0.86 g, and the yield was 84.31%.

Embodiment 2

[0022] Dissolve 2kg of food-grade sodium alginate in 3 times purified water, add 30g of 1% peracetic acid aqueous solution and stir for 3 hours, add 1.2kg of acetic acid, and stir thoroughly for 1 hour. Dissolve in double purified water, add 0.2kg of anhydrous sodium carbonate, stir for 2 hours, add 2L of isopropanol, stir evenly, let stand for 2 hours, centrifuge, and dry at 60°C for 3 hours. The produced medicinal sodium alginate is a white powder. According to the 2010 edition of the Chinese Pharmacopoeia, its chloride content is not more than 0.1%. The microorganisms meet the requirements of the Pharmacopoeia and meet the requirements for medicinal use. The obtained medicinal sodium alginate was 1.63 g, and the yield was 80.12%.

Embodiment 3

[0024] Dissolve 5kg of food-grade sodium alginate in 1 times purified water, add 50g of 3% peracetic acid aqueous solution and stir for 3 hours, add 5kg of acetic acid, and stir thoroughly for 2 hours. Dissolve in purified water, add 0.8kg of anhydrous sodium carbonate, stir for 2 hours, add 5L isopropanol, stir evenly, let stand for 2 hours, centrifuge, and dry at 60°C for 3 hours. The produced medicinal sodium alginate is a white powder. According to the 2010 edition of the Chinese Pharmacopoeia, its chloride content is not more than 0.1%. The microorganisms meet the requirements of the Pharmacopoeia and meet the requirements for medicinal use. The obtained medicinal sodium alginate was 4.07g, and the yield was 79.80%.

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Abstract

The invention discloses a production technology of medical sodium alginate. The production technology comprises the following steps of: 1, dissolving food-grade sodium alginate by using purified water to obtain an aqueous solution of the sodium alginate, adding a decolorizing oxidant into the aqueous solution of the sodium alginate, and fully stirring; 2, adjusting the PH (Potential of Hydrogen) to acid, heating and stirring the obtained solution, and carrying out acid coagulation and then centrifugally washing with water; 3, dissolving the precipitate by purified water, adding industrial-grade sodium carbonate, fully and uniformly stirring, and adjusting the pH to neutral; and 4, adding isopropanol, and carrying out crystallization, centrifugalization, and drying to obtain the sodium alginate solid. The sodium alginate obtained by using the method is high in effective ingredient content and low in impurity content, has a controlled content of microorganism, and reaches medicine standard grade.

Description

technical field [0001] The invention relates to a method for medicinal sodium alginate. Background technique [0002] Sodium alginate is a natural polysaccharide, which has the stability, solubility, viscosity and safety required by the excipients of pharmaceutical preparations. It can be used as a suspending agent and release retarder in pharmaceuticals. Sodium alginate used in pharmaceutical production usually has higher requirements on chloride and microorganisms. At present, the sodium alginate used in various industries is basically obtained from crude alginate extracted from seaweed, which is obtained through precipitation and sodium carbonate. The sodium alginate prepared by this method has high impurity content and darker color, and the microorganisms cannot be controlled. The method of extraction is rough, and it is difficult to reach the limit of medicinal requirements. Contents of the invention [0003] What the present invention aims to solve is the technica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/04
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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