Magnetic polylactic acid tissue engineering bracket

A tissue engineering scaffold, polylactic acid technology, applied in medical science, prosthesis and other directions, can solve the problems of cumbersome steps in the drug delivery process, and achieve the effect of reducing cumbersome steps

Inactive Publication Date: 2013-10-23
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional magnetic targeted drug delivery system often uses an external magnetic field as the driving force for drug aggregation, which makes the drug delivery process cumbersome.

Method used

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  • Magnetic polylactic acid tissue engineering bracket
  • Magnetic polylactic acid tissue engineering bracket
  • Magnetic polylactic acid tissue engineering bracket

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 2g of polyracemic lactic acid was dissolved in 20ml of methylene chloride, and 0.15g of Fe with particle size less than 50nm 3 o 4 The powder and 19g of NaCl with a particle size of 300-400 microns are mixed evenly, then added to the fully dissolved polyracemic lactic acid solution, stirred evenly, and poured into a mold. Let the solvent fully volatilize naturally, dry in vacuum at room temperature for 6 hours, add distilled water to fully leach, so that the porogen NaCl is dissolved, and the Fe-containing 3 o 4 polylactic acid magnetic tissue engineering scaffold.

Embodiment 2

[0023] 10g of poly-L-lactic acid is dissolved in 100ml of chloroform, and 2g of Fe with a particle size of less than 5 microns 3 o 4 The powder and 20g of NaCl with a particle size of 0-100 microns are mixed evenly, then added to the fully dissolved poly-L-lactic acid solution, stirred evenly, and the mixed solution is cast on a petri dish, and the chloroform is naturally volatilized in a fume hood at room temperature. membrane. Put the petri dish into a vacuum drying oven for 48 hours to vacuum dry. Then the film was taken out, crushed with a mortar, and the material was hot-pressed on a vulcanizer at 170° C. and a pressure of 15 MPa using a mold. Release the mold, wait for the temperature of the material to drop to room temperature, add distilled water to fully leach, so that the porogen NaCl is dissolved, and the Fe-containing 3 o 4 polylactic acid magnetic tissue engineering scaffold.

Embodiment 3

[0025] 5g poly-D-lactic acid was dissolved in 40ml methylene chloride, and 0.2g of Fe with a particle size less than 100nm 3 o 4 Add the powder into the fully dissolved poly-D-lactic acid solution, stir evenly, and put it into a vacuum freeze dryer after quick-freezing in liquid nitrogen, so that the solvent is fully volatilized, and the Fe-containing 3 o 4 Polycaprolactone Magnetic Scaffold for Tissue Engineering.

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Abstract

The invention discloses a magnetic polylactic acid tissue engineering bracket. A magnet tissue engineering bracket suitable for targeting of a magnetic targeting medicine feeding system is produced by adding Fe3O4 into a polylactic acid tissue engineering bracket and is a multiporous material containing the Fe3O4; the polylactic acid comprises poly-L-lactic acid, poly-R-lactic acid or poly-dl-lactic acid. The toxic action of medicines to the whole body is reduced, a complicated step of the medicine feeding process is reduced, and the magnetic polylactic acid tissue engineering bracket can be used for other treatment measures taking magnetism as targeting.

Description

technical field [0001] The invention relates to a magnetic polylactic acid tissue engineering support. Background technique [0002] The primary purpose of the development of tissue engineering technology is to apply it clinically to treat diseases caused by tissue loss or organ failure. Traditional treatment methods, including organ transplantation, surgical reconstruction, use of mechanical devices and regular infusion of drugs, etc., are not only expensive but also often ineffective in achieving the therapeutic goals. [0003] With the development of life sciences, physics, chemistry, and materials, tissue engineering emerges as the times require, which fundamentally solves the problem of treatment of dysfunction or loss caused by tissue and organ defects. The basic method is to amplify high-concentration tissue cells cultured in vitro and adsorb them on an extracellular matrix with good biocompatibility that can be gradually degraded and absorbed by the human body. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/02A61L27/56A61L27/54
Inventor 葛建华杨上游
Owner SHANDONG UNIV
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