Magnetic resonance spectroscopy with automatic phase and b0 correction using interleaved water reference scan

Abstract

A magnetic resonance (MR) sequence (14)is performed, including: applying a preparatory MR sub-sequence (S prep )providing water signal suppression; performing a magnetic resonance spectroscopy (MRS) sub-sequence (S MRS )after applying the preparatory MR sub-sequence to acquire H MRS data with water signal suppression; and performing an MR reference sub-sequence (S Ref )to acquire MR reference data. The MR reference sub-sequence is performed after the MRS sub-sequence. Phase and B0 correction of the H MRS data with water signal suppression are performed using the MR reference data to generate corrected MRS data. The excitation pulse (g)of the MR reference sub-sequence has a flip angle of less than or equal to o, and more preferably has a flip angle of less than or equal to 3 o.In some embodiments the MR sequence has a total repetition time (TR) of 2000 msec or less.

Description

technical field [0001] The following relates to magnetic resonance techniques, magnetic resonance spectroscopy techniques, magnetic resonance imaging techniques, medical imaging techniques, and related techniques. Background technique [0002] Magnetic resonance (MR) is a known technique useful in medical diagnosis, veterinary practice, forensic science, archaeology, and the like. most commonly through excitation, spatial encoding, and readout 1 H magnetic resonance signals to generate MR images. Further information can be obtained from Magnetic Resonance Spectroscopy (MRS), in which a spectrum of the MR response is acquired and analyzed. For example, the MRS can be parsed by the 1 H MR signals to distinguish those originating from different chemical environments—for example, water (H 2 O), fat, tissue, or other hydrocarbons, and so on—the hydrogen in hydrogen emits many different compositional signals. MRS can be performed at a single location (termed "single voxel spe...

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Problems solved by technology

[0004] The problem with this approach is that the extra scan without water suppression substantially increases the total scan time

Furthermore, since the water reference signal and the MRS signal are generated from different scans, the reference (non-water suppressed) signal may have a different phase compared to the MRS signal due to system instability distortion and / or B0 drift, which may reduce the effectiveness of the phase and / or B0 correction

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