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Blood separation system and method for a dry test strip

A technology for test strips and blood, applied in the fields of biochemical equipment and methods, specific-purpose bioreactors/fermenters, analytical materials, etc., can solve problems such as limited production needs

Inactive Publication Date: 2013-11-13
POLYMER TECH SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The design of dry test strips and carriers is also limited by the production needs of the strips

Method used

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  • Blood separation system and method for a dry test strip
  • Blood separation system and method for a dry test strip
  • Blood separation system and method for a dry test strip

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Embodiment approach

[0027]Embodiments include the use of PHA-P lectin (phase bean agglutinin) to slow the flow of red blood cells. The concentration of PHA-P was initially 100mg / 100ml solution, and then decreased to 50mg / 100ml because D-23 slowed down the plasma flow. Applicants note that D-23 has never been used as an erythrocyte separation layer. D-23 is strongly hydrophobic, and thus the sample does not readily penetrate D-23. To facilitate sample flow, the D-23 layer must be made more hydrophilic. Applicants have tested various other red blood cell separation layers for analyte strips, but none provided the performance of the chemically enhanced D-23 layer described in this application. Separation layers attempted include: Whatman's Fusion5, Whatman's VF2, Ahlstrom Grade142 and Ahlstrom Grade144. When thus treated, other borosilicate glass fiber layers with similar properties will exhibit similar performance as described herein.

[0028] To increase the hydrophilicity of D-23, polyvinyl a...

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Abstract

A dry test strip layer for filtering red blood cells includes a Borosilicate Glass Fiber layer and lectin, impregnated in the borosilicate layer, such that the dry test strip is configured to filter red blood cells from a blood sample.

Description

technical field [0001] The described blood separation systems and methods for dry test strips generally relate to bodily fluid analysis systems including disposable test strips, which are particularly useful for point-of-care testing of specific analytes in blood. The described blood separation systems and methods for dry test strips provide improved methods for blood separation. Background technique [0002] Blood separation systems and methods for dry test strips generally relate to bodily fluid analysis systems including disposable test strips and spectrophotometric sensing devices, particularly for on-site testing of specific analytes in blood. [0003] The levels of specific analytes in blood and other bodily fluids are often used to diagnose disease, determine risk factors for disease, monitor the progress of treatment, or determine the presence of illicit drugs. For example, the levels of various cholesterol and triglycerides, which are important risk indicators for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34
CPCG01N2333/42G01N33/538G01N33/558G01N33/491C12M1/34G01N33/48G01N33/566G01N33/68
Inventor G·休斯A·P·帕特瓦尔丹D·麦克切斯尼R·D·哈伯H·托梅奥F·M·拉杜卡
Owner POLYMER TECH SYST
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