Tagatose tablet excipient, medicinal tablet and preparation method of medicinal tablet

Abstract

The invention discloses a tagatose tablet excipient, which consists of the following components in percentage by weight: 88-96 percent of tagatose, 1-5 percent of starch octenyl succinate anhydride, 1-5 percent of silicon dioxide and 1-5 percent of porcellanite. The tagatose tablet excipient has high flowability, high molding property and high release property, and can be prepared into a medicinal tablet together with a medicament and water by directly tableting. The invention further discloses a medicinal tablet, which consists of the following components in percentage by weight: 75-85 percent of medicinal active ingredients, 5-15 percent of a tagatose tablet excipient and 5-15 percent of a water raw material. The tagatose tablet excipient and the medicinal active ingredients can react with each other in a non-incompatible way, have high solubility and high flowability, and are suitable for directly tableting various medicaments. The invention further discloses a preparation method of the medicinal tablet. The method is easy for preparing, implementing, operating and controlling.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a tagatose tablet excipient which can be directly compressed and flows easily, a drug tablet prepared by using the tagatose tablet excipient, and a drug tablet The preparation method of the agent. Background technique [0002] Tablet accounts for more than one-third of all pharmaceutical dosage forms and is a very important pharmaceutical dosage form. Excipients play a vital role in drug stability and absorption efficiency, and are the core of drug tablet making. Appropriate tablet excipients are required to be safe, non-toxic, have no side effects, have no incompatibility or reaction with the main drug, and have good fluidity, so that the main drug can be dispersed evenly and have a large adsorption force to the main drug. It is suitable for direct tablet compression. The prepared tablet has the advantages of high adhesion, good formability, good lubricity, good mold release, strong hy...

AI Technical Summary

Problems solved by technology

In Example 8, ordinary microcrystalline cellulose was used as an excipient to carry out tablet compression of disodium clometris phosphate tablet. When the tablet compression speed reached 30,000 tablets / hour, the friability was as high as 38%. When reaching 50000 tablets / hour, then can not be compressed into tablet, carry out the disodium clomedipate tablet tabletting with silicified microcrystalline cellulose as excipient, when the tabletting speed reaches 50000 tablets / hour, although the tablet is still Maintain good strength, but the brittleness reaches 2.5%, and the brittleness is still high