Tagatose tablet excipient, medicinal tablet and preparation method of medicinal tablet

A technology for tagatose tablets and excipients, applied in the field of medicine, can solve the problems of high brittleness and cannot be pressed into tablets, etc., and achieve the effects of high hydrophilicity, good formability and high adhesive force

Active Publication Date: 2012-10-03
安吉东来药用辅料有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In Example 8, ordinary microcrystalline cellulose was used as an excipient to carry out tablet compression of disodium clometris phosphate tablet. When the tablet compression speed reached 30,000 tablets/hour, the friability was as high as 38%. When reaching 50000 tablets/hour, then can not be compre

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0048] Anhydrous disodium chloromethanediphosphate 800g;

[0049] Tagatose 91g;

[0050] Starch octenyl succinate 3g;

[0051] Silica 3g;

[0052] Kaolin 3g;

[0053] water 100g;

[0054] Dry and pulverize tagatose, octenyl succinic acid starch ester, silicon dioxide and kaolin together and pass through a 1mm sieve, then add anhydrous disodium chloroformate and water and mix evenly, use 9× in the tableting device 20mm punching machine, made into anhydrous chlormedate disodium pharmaceutical tablets with an average weight of 1190mg (±2%).

Embodiment 2

[0056] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0057] Anhydrous disodium chloromethanediphosphate 800g;

[0058] 94g tagatose;

[0059] Starch octenyl succinate 2g;

[0060] Silica 2g;

[0061] Kaolin 2g;

[0062] water 100g;

[0063] Dry and pulverize tagatose, octenyl succinic acid starch ester, silicon dioxide and kaolin together and pass through a 1mm sieve, then add anhydrous disodium chloroformate and water and mix evenly, use 9× in the tableting device 20mm punching machine, made into anhydrous chlormedate disodium pharmaceutical tablets with an average weight of 1190mg (±2%).

[0064] Prepare the anhydrous chlormedipate disodium pharmaceutical tablet (tablet A) of embodiment 1 and the anhydrous chlormedipate disodium pharmaceutical tablet (tablet B) of embodiment 2 under different tabletting speeds, and investigate Its crushing strength and fragility, the specific test results ...

Embodiment 3

[0069] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0070] Anhydrous disodium chloromethanediphosphate 800g;

[0071] Tagatose 88g;

[0072] Starch octenyl succinate 4g;

[0073] Silica 4g;

[0074] Kaolin 4g;

[0075] water 100g;

[0076] Dry and pulverize tagatose, octenyl succinic acid starch ester, silicon dioxide and kaolin together and pass through a 1mm sieve, then add anhydrous disodium chloroformate and water and mix evenly, use 9× in the tableting device 20mm punching machine, made into anhydrous chlormedate disodium pharmaceutical tablets with an average weight of 1190mg (±2%).

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PUM

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Abstract

The invention discloses a tagatose tablet excipient, which consists of the following components in percentage by weight: 88-96 percent of tagatose, 1-5 percent of starch octenyl succinate anhydride, 1-5 percent of silicon dioxide and 1-5 percent of porcellanite. The tagatose tablet excipient has high flowability, high molding property and high release property, and can be prepared into a medicinal tablet together with a medicament and water by directly tableting. The invention further discloses a medicinal tablet, which consists of the following components in percentage by weight: 75-85 percent of medicinal active ingredients, 5-15 percent of a tagatose tablet excipient and 5-15 percent of a water raw material. The tagatose tablet excipient and the medicinal active ingredients can react with each other in a non-incompatible way, have high solubility and high flowability, and are suitable for directly tableting various medicaments. The invention further discloses a preparation method of the medicinal tablet. The method is easy for preparing, implementing, operating and controlling.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a tagatose tablet excipient which can be directly compressed and flows easily, a drug tablet prepared by using the tagatose tablet excipient, and a drug tablet The preparation method of the agent. Background technique [0002] Tablet accounts for more than one-third of all pharmaceutical dosage forms and is a very important pharmaceutical dosage form. Excipients play a vital role in drug stability and absorption efficiency, and are the core of drug tablet making. Appropriate tablet excipients are required to be safe, non-toxic, have no side effects, have no incompatibility or reaction with the main drug, and have good fluidity, so that the main drug can be dispersed evenly and have a large adsorption force to the main drug. It is suitable for direct tablet compression. The prepared tablet has the advantages of high adhesion, good formability, good lubricity, good mold release, strong hy...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/26A61K9/20A61K31/663A61P3/14A61P19/10
Inventor 李青青阮晖吴慧斌刘松柏陈放诸文颖
Owner 安吉东来药用辅料有限责任公司
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