Topiramate medicine composition

The technology of a composition and topiramate, which is applied in the field of topiramate pharmaceutical composition and its preparation, can solve the problems of easy cracking of tablets, cumbersome preparation method, cumbersome operation process, etc., and achieve quality assurance and safety, simple process, and particle size uniform effect
CN103417501AActive Publication Date: 2013-12-04BEIJING WINSUNNY PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING WINSUNNY PHARMA CO LTD
Publication Date
2013-12-04

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Abstract

The invention relates to a topiramate medicine composition. In the composition, pregelatinized starch is added, the stability of the active components of topiramate is increased, and therefore the quality and security of the composition can be ensured. In the composition, the pregelatinized starch also plays a role of a dry binder, the hardness and the friability of the composition are ensured, the amounts of auxiliary materials are decreased, and the cost is saved. The invention also relates to a preparation method for the topiramate medicine composition. The preparation method comprises a dry granulation technology. The preparation method has simple technology. The finished products after granulation are epigranular, which is convenient for storage and transportation. The topiramate medicine composition is suitable for industrialized production.
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Description

[0001] technical field

[0002] The invention relates to a topiramate pharmaceutical composition and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique

[0003] Epilepsy is a neurological disease, usually brain dysfunction caused by sudden abnormal excessive discharge of brain cells caused by brain lesions. It is estimated that the incidence of epilepsy in different populations around the world is about 0.3% to 0.5%, and the prevalence is about With 5 to 10 people in every 1000 people, epilepsy seriously threatens people's health and affects people's daily life.

[0004] Topiramate, a new type of antiepileptic drug that replaces monosaccharides with sulfamic acid esters, was developed by Johnson & Johnson in the United States and was launched in the UK under the trade name Topamax in 1995. In the electrophysiological and biochemical studies on neurons cultured in vitro, it was found that there are three mechanisms for t...

Claims

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