Method for extracting curculigo orchioides total glycoside matter from curculigo orchioides and application of curculigo orchioides total glycoside matter in preparing perimenopausal syndrome preventing and curing drugs

Abstract

The invention relates to a method for extracting curculigo orchioides total glycoside matter from curculigo orchioides and the application of the curculigo orchioides total glycoside matter in preparing perimenopausal syndrome preventing and curing drugs. The problem of extracting curculigo orchioides total glycosides from the curculigo orchioides to prepare the perimenopausal syndrome preventing and curing drugs can be effectively solved. The method comprises the steps that the curculigo orchioides is smashed to be powder, the powder is soaked in ethyl alcohol, reflux extraction is carried out for 2 times, filtering is carried out, extracting solutions recycle the ethyl alcohol in a decompression mode until the ethyl alcohol has no alcohol taste, concentration is carried out, concentrated solutions are dispersed with distilled water added, and sample liquid is obtained; an AB-8 large hole is used for absorbing resin on the sample liquid, elution is carried out through the distilled water, and water liquid is abandoned; the elution is carried out for two times through the ethyl alcohol with different volume concentrations, eluants of the second time are collected, the ethyl alcohol is recycled in a decompression mode, dry powder is obtained through concentration, and the curculigo orchioides total glycosides are obtained. The curculigo orchioides total glycosides are effectively applied to the perimenopausal syndrome preventing and curing drugs, the application of the curculigo orchioides total glycosides in preparing the perimenopausal syndrome preventing and curing drugs is achieved, the raw materials in the method are abundant, the preparing method is unique, the operation is easy, the medicinal value of the curculigo orchioides is developed, and the method is the innovation of the perimenopausal syndrome preventing and curing drugs.

Description

technical field [0001] The invention relates to medicine, in particular to a method for extracting total glycosides of Curculigo curculiculata and its application in preparing medicines for preventing and treating perimenopausal syndrome. Background technique [0002] Curculigo orchioides is the rhizome of the perennial herbaceous plant Curculigoorchioides Gaertn. of Amaryllidaceae. It is warm in nature and pungent in taste. Insufficiency of kidney yang, impotence and nocturnal emission, consumptive tuberculosis and internal injuries, and pain in muscles and bones. Its leaves are like that of grass, and its rhizome is long-term taken to benefit the essence and nourish the marrow, and increase the spirit, so it is called curculigo. Modern research on Curculigo curculigo in recent years shows that the chemical components of Curculigo curculigo are mainly saponins, phenols, phenolic glycosides and lignans, a small amount of organic acids and alkaloids, etc. Curculigoside is th...

AI Technical Summary

Problems solved by technology

[0010] Modern medicine often adopts hormone replacement therapy (Hormon Replacement Therapy, HRT) for the treatment of perimenopausal syndrome. Injection, compound ethinyl estradiol medroxyprogesterone capsules, compound procaine hydrochloride capsules, estradiol valerate, chlorphenestradiol dripping pills, etc. Although the short-term curative effect of HRT is definite, long-term use of estrogen can increase intrauterine It is found that HRT can increase the risk of cardiovascular and cerebrovascular and other serious side effects, which obviously limits the clinical application of this method.

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