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New use of notoginsenoside R1

A technology of Panax notoginseng saponins and new uses, applied in the field of traditional Chinese medicine, can solve the problems such as not seen Panax notoginseng saponins R1 and the like

Inactive Publication Date: 2013-12-18
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although there are technical reports on the extraction and separation of notoginseng saponin R1 from Panax notoginseng, there is no related report that notoginseng saponin R1 can be used as an active ingredient in the preparation of drugs or health food for the prevention and / or treatment of inflammatory diseases of the digestive system

Method used

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  • New use of notoginsenoside R1
  • New use of notoginsenoside R1
  • New use of notoginsenoside R1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0038] 1. Experimental materials

[0039] 1.1 Medicinal materials

[0040] Notoginsenoside R1 (R1, CAS: 80418-24-2, molecular weight 933.13, HPLC purity ≥ 98%, produced by Sigma); dextran sodium sulfate (DSS, CAS: 9011-18-1, molecular weight 35000-44000 , produced by MPBiomedical LLC); sulfasalazine (SASP, CAS: 599-79-1, molecular weight 398.39, HPLC purity ≥ 98%, produced by Sigma).

[0041] 1.2 Experimental animals

[0042]C57BL / 6 mice (8-10 weeks) with a body weight of 20±2g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal certificate number: SYXK (Shanghai) 2009-0069. Placed in a conventional feeding environment, free access to food and water.

[0043] 2. Experimental method

[0044] 2.1 Establishment of ulcerative colitis model

[0045] Select C57BL / 6 mice (20±2g, 8-10 weeks) with uniform body weight, and refer to the international general method of ulcerative colitis modeling (Gastroenterology, 1990, 98: ...

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Abstract

The invention discloses a new use of notoginsenoside R1 in the preparation of medicines for preventing and / or treating the inflammatory diseases of the digestive system or healthcare foods as an active component. Experiment results show that the notoginsenoside R1 has an inhibition effect on the NF-kappa B signal pathway, and has substantial prevention and treatment effects on the NF-kappa B signal pathway mediated ulcerative colonitis, so the notoginsenoside R1 can be developed to medicines for preventing and / or treating the inflammatory diseases of the digestive system or healthcare foods. The new use urges the notoginsenoside R1 to fully perform its medicinal values, and is very important for researching and applying Panax Notoginseng.

Description

technical field [0001] The present invention relates to a new application of notoginseng saponin R1, specifically relates to the application of notoginseng saponin R1 in the preparation of medicines or health food for the prevention and / or treatment of digestive system inflammatory diseases, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] Ulcerative colitis (UC) is a chronic nonspecific ulcerative rectal and colitis of unknown etiology, which together with Crohn's disease (CD) constitutes inflammatory bowel disease (Inflammatory bowel disease, IBD) . The clinical manifestations are mainly diarrhea, abdominal pain, mucus pus and blood in the stool and recurrent attacks. Colonoscopy showed mucosal hyperemia, edema, erosion, bleeding and ulcers. Foreign epidemiological data show that the disease can occur at any age, and it is more common in young adults aged 20-40. In recent years, with the improvement of living standards an...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P1/00A61P1/04A61P1/12A23L1/29A23L33/00
CPCY02A50/30
Inventor 窦薇王峥涛张晶晶杨莉丁丽丽
Owner SHANGHAI UNIV OF T C M
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