Liquid composition for oral cavity and method for stable addition of components to composition
A technology for a composition and oral cavity, which is applied in the directions of nursing oral cavity, pharmaceutical combination, medical preparations of inactive ingredients, etc., can solve the problems of difficult coexistence of preparation palatability, ethanol stimulation, and difficulty in ensuring appearance stability, and achieves appearance stability. Improved, palatable effects
Active Publication Date: 2013-12-18
LION CORP
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Problems solved by technology
[0003] Although any of the prior art allows the mixing of ethanol, however, in recent years, there is a problem of irritation caused by ethanol when a low-irritating feeling of use is required, and a composition without ethanol tends to be desired
[0004] However, when ethanol is not mixed, there are problems in that it is difficult to ensure the stability of the appearance of a composition mixed with a cationic fungicide and hydroxyethylcellulose dimethyl diallyl ammonium chloride, and it is difficult to ensure both non-irritating and Time-dependent stability of appearance
Furthermore, astringency, bitterness, and peculiar taste from the cationic fungicide and hydroxyethyl cellulose dimethyl diallyl ammonium chloride will also be produced, and the effects of the two components and the palatability of the preparation are difficult to coexist
Method used
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Embodiment
[0062] Hereinafter, although an Example, a comparative example, and a prescription example demonstrate this invention concretely, this invention is not limited to a following example. In addition, in the following examples, % represents mass % unless there is a particular limitation.
[0063] [Example, comparative example]
[0064] Liquid oral compositions of the compositions shown in Tables 1 to 4 were prepared by a usual method, and the following evaluations were performed. The results are shown in Tables 1-4.
[0065] (I) Tartar Adhesion Inhibition Effect
[0066] 2 mL of the liquid oral composition was injected into each of the 24-well plates, and three mirror-polished hydroxyapatite plates (radius 0.35 cm×height 0.35 cm, hereinafter referred to as HAP plates) manufactured by Pentax Co., Ltd. were immersed. )30 seconds.
[0067] Add 2 mL of buffer solution in which 10449 strains of Streptococcus mutans (Streptococcus mutans) are dispersed in a manner such that the turb...
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Provided is a liquid composition for an oral cavity, which is excellent in terms of a plaque deposition-inhibiting effect and a bactericidal effect against the Streptococcus mutans in plaque; has improved stability of appearance and is palatable; and is free of ethanol. The liquid composition for the oral cavity is characterized in that (A) a cationic bactericide and (B) a hydroxyethyl cellulose dimethyl diallylammonium chloride are added to a liquid composition for the oral cavity that is substantially ethanol-free; (C) anethole is also used at a mass ratio of component (C) / [component (A) + component (B)] that is within a range of 0.1 to 10; and (D) a polyhydric alcohol and / or (E) a nonionic surfactant are added. Also provided is a method for the stable addition of the components (A) and (B) to the composition whereby the components (A) and (B) are added to the liquid composition for the oral cavity, the component (C) is also used within a range of (C) / [(A)+(B)] of 0.1 to 10; and the components (D) and / or (E) are added.
Description
technical field [0001] The present invention relates to an ethanol-free liquid composition for oral cavity and a method for stabilizing and mixing components in the composition, which exhibits an excellent effect of inhibiting the adhesion of tartar on the tooth surface and is excellent against Streptococcus mutans in tartar In addition to the bactericidal power, the appearance stability (no sediment) is improved, and the palatability is also good. Background technique [0002] Suppression of dental plaque is important in the prevention of periodontal disease and dental caries, and compositions for oral cavity containing a bactericide for the purpose of suppressing dental plaque are widely used. Cationic bactericides among these bactericides are widely used because they have oral bacteria sterilizing effects, plaque suppressing effects, and gingivitis-improving effects. In addition, Patent Document 1 (Japanese Unexamined Patent Publication No. 2001-64137) proposes a liquid ...
Claims
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Login to View More IPC IPC(8): A61K8/49A61K8/33A61K8/34A61K8/73A61K31/4425A61K47/08A61K47/10A61K47/34A61Q11/00
CPCA61K8/33A61K8/345A61K8/416A61K8/4926A61K8/731A61K2800/30A61Q11/00A61Q17/005A61P1/02A61K8/34A61K8/49A61K8/73A61K31/4425
Inventor 川口尚子
Owner LION CORP