Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Slit waveguide based pathogen detection method

A pathogen detection and slit waveguide technology, applied in the field of pathogen detection, can solve the problems of large size, complex structure, high cost, etc., and achieve the effects of rapid light field changes, obvious light field changes, and high integration

Active Publication Date: 2015-07-08
ZHEJIANG UNIV OF TECH
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the shortcomings of the existing pathogen detection technology, such as complex structure, large size, and high cost, the present invention provides a slit-based waveguide that simplifies the structure, reduces the size, and reduces the cost while meeting high detection efficiency and fast response. pathogen detection method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Slit waveguide based pathogen detection method
  • Slit waveguide based pathogen detection method
  • Slit waveguide based pathogen detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] The present invention will be further described below in conjunction with the accompanying drawings.

[0025] Refer to Figure 1~ Figure 4 , a pathogen detection method based on a slit waveguide, the virus detection component used in the detection method includes straight waveguides arranged side by side up and down, a slit waveguide is arranged between adjacent up and down straight waveguides, and the width of the slit waveguide is 175nm ~225nm, the side wall of the slit waveguide is attached with the antigen / antibody of the virus to be detected, the slit waveguide is a detection channel for the blood sample to be detected to flow through, and the refractive index of the straight waveguide material is higher than that of the slit The refractive index of the waveguide is high; the detection method comprises the following steps:

[0026] 1) First, use weak acid to corrode the surface of the waveguide to make it no longer smooth;

[0027] 2) attaching the virus antigen / ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
widthaaaaaaaaaa
sizeaaaaaaaaaa
refractive indexaaaaaaaaaa
Login to View More

Abstract

The invention relates to a slit waveguide based pathogen detection method. A virus detection assembly for implementing the method comprises straight waveguides arranged side by side up and down, there is a slit waveguide between adjacent up-and-down straight waveguides, and the refractive index of the material of the straight waveguides is higher than the refractive index of the slit waveguide. The detection method comprises the following steps: 1, carrying out corrosion treatment of the surfaces of the waveguides by a weak acid; 2, adhering the antigen / antibody of a virus for detection to the sidewall of the slit waveguide; 3, adding a non-virus normal blood sample into the slit waveguide, allowing light to pass through the straight waveguides, and detecting the light field intensity of the slit waveguide in an initial state as a reference value; and 4, detecting the light field intensity of the slit waveguide after a blood sample for detection flows through the slit waveguide, determining that the virus for detection is contained if a difference between the light field intensity in the slit waveguide and the reference value is greater than a preset threshold, and determining that the virus for detection is not contained if not. The method has the advantages of high detection efficiency, fast response, structure simplification, size reduction and cost reduction.

Description

technical field [0001] The invention relates to the field of pathogen detection, in particular to a pathogen detection method. Background technique [0002] In the existing pathogen detection technology, the conventional pathogen detection is invasive detection, and the medical treatment is slow, the efficiency is low, and the intelligence is not high. [0003] Someone proposed to use genetic technology to detect pathogens, for example, the patent application number is 200680050988.6, and the title of the invention is: Chinese invention patent application for the method of detecting pathogens; another person proposed to use up-conversion luminescence technology to realize pathogen detection, for example, the patent number is: 200410034105.5, The Chinese invention patent of the invention name is up-conversion luminescent biosensor. [0004] Using genetic technology to detect pathogens has high detection accuracy, but there are technical defects: the entire detection equipmen...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/569G01N21/41
Inventor 乐孜纯董文
Owner ZHEJIANG UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com