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A kind of valacyclovir hydrochloride capsule preparation and preparation method thereof

A technology of valacyclovir hydrochloride and capsules, which is applied in the field of valacyclovir hydrochloride capsule preparations and its preparation, can solve the problems of no patent application for valacyclovir hydrochloride sustained-release preparations, and achieve zero-order release and type The effect of less and low production cost

Inactive Publication Date: 2015-12-09
北京太禾利和科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no patent application for valacyclovir hydrochloride sustained-release preparation

Method used

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  • A kind of valacyclovir hydrochloride capsule preparation and preparation method thereof
  • A kind of valacyclovir hydrochloride capsule preparation and preparation method thereof
  • A kind of valacyclovir hydrochloride capsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017]

[0018]

[0019] Preparation Process:

[0020] Prescription quantity takes by weighing valacyclovir hydrochloride, ethyl cellulose and highly substituted hydroxypropyl cellulose, adds in ethanol, stirs to dissolve, and adds to the liquid paraffin containing 0.5% (v / v) Span 80 under stirring condition During the process, gradually raise the temperature to 40°C, keep stirring for 6 hours, raise the temperature to 70°C, stir for 1 hour, and filter under reduced pressure to obtain valacyclovir hydrochloride sustained-release pellets, which are filled into capsule shells.

Embodiment 2

[0022]

[0023] Preparation Process:

[0024] Prescription quantity takes by weighing valacyclovir hydrochloride, ethyl cellulose and highly substituted hydroxypropyl cellulose, adds in ethanol, stirs to dissolve, and adds to the liquid paraffin containing 2% (v / v) Span 80 under stirring condition During the process, gradually raise the temperature to 40°C, keep stirring for 6 hours, raise the temperature to 70°C, stir for 1 hour, and filter under reduced pressure to obtain valacyclovir hydrochloride sustained-release pellets, which are filled into capsule shells. Example 3

Embodiment 3

[0025]

[0026] Preparation Process:

[0027] Prescription quantity takes by weighing valacyclovir hydrochloride, ethyl cellulose and highly substituted hydroxypropyl cellulose, adds in ethanol, stirs to dissolve, and adds to the liquid paraffin containing 0.5% (v / v) Span 80 under stirring condition During the process, gradually raise the temperature to 40°C, keep stirring for 6 hours, raise the temperature to 70°C, stir for 1 hour, and filter under reduced pressure to obtain valacyclovir hydrochloride sustained-release pellets, which are filled into capsule shells.

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PUM

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Abstract

The invention discloses a valaciclovir hydrochloride capsule preparation which comprises a capsule shell and contents, wherein the contents are valaciclovir hydrochloride sustained-release pellets which are prepared according to a method which comprises the following steps that valaciclovir hydrochloride, ethyl cellulose and high-substituted hydroxyproxyl cellulose are dissolved in ethyl alcohol to be added into liquid paraffin containing surface active agents under the condition of stirring, the temperature is gradually raised to 38-42 DEG C, thermal-insulation stirring is carried out for 4-8 hours, the temperature is raised to 68-72 DEG C, stirring is carried out for 0.5-2 hours, filtration under diminished pressure is carried out, and the valaciclovir hydrochloride sustained-release pellets are obtained. The valaciclovir hydrochloride capsule preparation not only greatly reduces the amount of sustained-release materials but also eliminates the phenomenon of initial burst releasing of medicine.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an antiviral drug preparation, in particular to a valacyclovir hydrochloride capsule preparation and a preparation method thereof. Background technique [0002] Valacyclovir hydrochloride is the prodrug of acyclovir, which is absorbed rapidly after oral administration and is quickly converted into acyclovir in the body. Its antiviral effect is caused by the effect of the parent acyclovir. After entering herpes-infected cells, it competes with deoxynucleoside for viral thymidine kinase or cellular kinase, and the drug is phosphorylated into activated acycloguanosine triphosphate, which acts as a substrate for viral DNA replication and competes with deoxyguanine triphosphate for viral DNA polymerase, thereby inhibiting viral DNA synthesis, showing antiviral efficacy. This product has a high curative effect on herpes simplex virus types Ⅰ and Ⅱ and varicella zoster vi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K31/522A61K47/38A61P31/22
Inventor 余炎炎
Owner 北京太禾利和科技有限公司