Nystatin expandable vaginal suppository, and preparation method and detection method thereof
A vaginal expansion suppository and nystatin technology, which is applied in the directions of suppository delivery, measuring device, pharmaceutical formulation, etc., can solve the problems of easily contaminated clothes, difficult to clean, and little research on nystatin suppositories, etc., to avoid secondary infection, The effect of preventing outflow
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Embodiment 1
[0095]
[0096] Preparation:
[0097] 1) Preparation of drug-containing matrix:
[0098] a. heating and melting hypromellose and fractionated palm oil in a water bath to obtain a melt;
[0099] b. mixing nystatin with the melt of step a evenly to obtain a drug-containing matrix;
[0100] 2) Pour the drug-containing matrix into a suppository mold, insert a tampon, cool and shape, and make 100 conical suppositories, each weighing about 3.4g.
Embodiment 2
[0102]
[0103] Preparation:
[0104] 1) Preparation of drug-containing matrix:
[0105] a. Semi-synthetic palm oil ester and propylene glycol stearate are placed in a water bath for heating and melting to obtain a melt;
[0106] b. Take hydroxypropyl-β-cyclodextrin and add 3 times the amount of water, fully grind to a paste with a moisture content of less than 5%, add nystatin under grinding, mix well, and freeze-dry to obtain clathrate thing;
[0107] c. Mix the clathrate of step b and the melt of step a uniformly to prepare a drug-containing matrix;
[0108] 2) Pour the drug-containing matrix into the suppository mold, insert the tampon, cool and shape, and make 100 cylindrical suppositories, each weighing about 5.0g.
Embodiment 3
[0110]
[0111] Preparation method: make 100 rod-shaped suppositories according to the method in Example 2, each weighing about 1.9g.
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