Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of microporous polysaccharide microspheres

A technology of polysaccharides and microspheres, which is applied in the field of preparation of microporous polysaccharide microspheres, which can solve the problems of unsatisfactory hemostatic effect, high price, and non-sticky plugging.

Inactive Publication Date: 2014-02-05
梁新丽
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process, epichlorohydrin was used as a cross-linking agent, which is a colorless oily liquid, toxic and narcotic, and potentially harmful to the human body; from the perspective of hemostatic effect, the water absorption rate is low and the water absorption speed is low. slow, and the hemostatic effect is not ideal, especially for active bleeding; the gel formed after absorbing water has poor viscosity and cannot effectively block damaged tissues and blood vessels. In active bleeding, hemostatic powder is not easy Quickly adheres to the bleeding site and is easily washed away by the blood flow. If the dressing is pressed on the hemostatic powder, the dressing is easily adhered by the blood clot, and it is easy to cause rebleeding when the dressing is uncovered. Therefore, the effect on active bleeding is not ideal. , and expensive

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preliminary emulsification: Take 100g of potato starch from which vegetable protein has been removed, add 50ml of water in a twin-screw extruder at a speed of 5ml / min, set the extrusion temperature to 180°C, and repeat the extrusion process 5 times to form a preliminary emulsification liquid;

[0027] Enzymatic hydrolysis and cross-linking: After the above-mentioned preliminary emulsion is allowed to cool, add 200ml of high-temperature resistant α-amylase solution (containing 3g of high-temperature resistant α-amylase) and 2g sodium trimetaphosphate prepared with pH 7.4 phosphate buffer , Stir the reaction at 2500 rpm at 80°C;

[0028] Emulsification reaction: While the above-mentioned stirring reaction, 200ml of polyethylene glycol 400 aqueous solution (containing polyethylene glycol 40060ml) was slowly added dropwise to the above-mentioned reaction liquid, and the reaction was stirred for 12 hours;

[0029] Washing and refining: After the reaction is completed, let the abov...

Embodiment 2

[0033] Preliminary emulsification: Take 100g of corn starch from which vegetable protein has been removed, add 200ml of water in a twin-screw extruder at a speed of 5ml / min, set the extrusion temperature to 230℃, and repeat the extrusion process 3 times to form a preliminary emulsification liquid;

[0034] Enzymatic hydrolysis and cross-linking: After the above-mentioned preliminary emulsion is allowed to cool, add 100ml of high temperature resistant α-amylase solution prepared with pH 7.4 phosphate buffer (containing 1g high temperature resistant α-amylase) and 5g sodium trimetaphosphate , Stir the reaction at a speed of 4000 rpm at 90°C;

[0035] Emulsification reaction: while the above stirring reaction, 300ml of polyethylene glycol 600 aqueous solution (including polyethylene glycol 600100ml) is slowly added dropwise to the above reaction solution, and the reaction is stirred for 24 hours;

[0036] Washing and refining: After the reaction is completed, let the above-mentioned re...

Embodiment 3

[0040] Preliminary emulsification: Take 100g of potato starch from which vegetable protein has been removed, add 100ml of water in a twin-screw extruder at a speed of 5ml / min, set the extrusion temperature to 250℃, and repeat the extrusion process 8 times to form a preliminary emulsification liquid;

[0041] Enzymatic hydrolysis and cross-linking: After the above-mentioned preliminary emulsion is allowed to cool, add 50ml of medium temperature α-amylase solution (containing 5g of high temperature resistant α-amylase) and 1g sodium trimetaphosphate prepared with phosphate buffer of pH 7.4. Stir the reaction at a speed of 2000 rpm at 55°C;

[0042] Emulsification reaction: While the above-mentioned stirring reaction, 300ml of polyethylene glycol 200 aqueous solution (containing polyethylene glycol 20030ml) was slowly added dropwise to the above-mentioned reaction liquid, and the reaction was stirred for 8 hours;

[0043] Washing and refining: After the reaction is completed, let the a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of microporous polysaccharide microspheres, which is characterized by comprising the following steps: preliminary emulsification, enzymolysis crosslinking, emulsification reaction, washing and refining, homogeneous decoloration and drying and packaging. According to the microporous polysaccharide microspheres prepared by the method provided by the invention, the method is simple and convenient, and the cost is low; the product is elastic spherical particles with tens of thousands of micropores in the surface, and has strong water absorption and a double-hemostasis mechanism as well as excellent safety and exact hemostasis effect.

Description

Technical field [0001] The invention relates to a method for preparing microporous polysaccharide microspheres, in particular to a method for preparing microporous polysaccharide microspheres with hemostatic effect. Background technique [0002] At present, a variety of new hemostatic materials have been developed at home and abroad. The commonly used hemostatic dressings include traditional gelatin sponge, alginate, collagen, and the newly emerged collagen complexes, polysaccharides and zeolites. Good results have been achieved in animal experiments and clinical applications, but different hemostatic materials have different coagulation mechanisms, and all of the above materials have certain defects. Among them, the absorption rate of gelatin sponge is slow, which generally takes more than 4 weeks. Therefore, it will increase the risk of wound infection and affect wound healing. Collagen sponge is derived from the collagen extract of animal tissues. Although it has excellent he...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L15/28A61L15/42C12P21/06
Inventor 梁新丽
Owner 梁新丽
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com