Method for preparing nano hydroxyapatite

A technology of nano-hydroxyapatite and powder, which is applied in the direction of nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of low product output, consumption, and poor uniformity, and achieve reduced feeding time, cheap and easy-to-obtain raw materials, The effect of reducing production costs

Inactive Publication Date: 2014-02-05
SUN YAT SEN UNIV
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  • Claims
  • Application Information

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Problems solved by technology

However, after the precipitation method product is dried, it is easy to agglomerate, and the particle size is different, and the uniformity is poor, and it is often necessary to introduce a surface dispersant; the hydrothermal method requires extremely high reaction conditions (high temperature, high pressure), and the productio

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  • Method for preparing nano hydroxyapatite

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0016] Example 1

[0017] In the first step, weigh 30.9g (CaNO 3 ) 2 · 4H 2 O and 13.2g (NH 4 ) 2 HPO 4 The powders were dissolved in deionized water and formulated to 0.2mol / L (CaNO 3 ) 2 · 4H 2 O solution and 0.2mol / L(NH 4 ) 2 HPO 4 Solution.

[0018] In the second step, with the aid of ultrasound and 1300rad / min mechanical stirring, the (NH 4 ) 2 HPO 4 Dropped to (CaNO 3 ) 2 · 4H 2 O, and use PEG2000 as a dispersant, adjust the pH to 10 with ammonia.

[0019] In the third step, aging for 24 hours after the dripping. The obtained product was centrifuged at 10000 r / min, 20min, and washed with water three times to obtain nano-hydroxyapatite.

[0020] The prepared nano-hydroxyapatite has a rod-like microscopic shape and is well dispersed; the length is about 120nm and the width is about 30nm (the aspect ratio is about (5:1).

Example Embodiment

[0021] Example 2

[0022] In the first step, weigh 8.856g (CaNO 3 ) 2 · 4H 2 O and 2.971g (NH 4 ) 2 HPO 4 The powders were dissolved in deionized water and formulated to 0.2mol / L (CaNO 3 ) 2 · 4H 2 O solution and 0.2mol / L(NH 4 ) 2 HPO 4 Solution.

[0023] In the second step, with the aid of ultrasound and 1100rad / min mechanical stirring, the (NH 4 ) 2 HPO 4 Dropped to (CaNO 3 ) 2 · 4H 2 O, and use PEG2000 as a dispersant, adjust the pH to 10 with ammonia.

[0024] In the third step, aging for 24 hours after the dripping. The obtained product was centrifuged at 10000 r / min, 20min, and washed with water three times to obtain nano-hydroxyapatite.

[0025] The microscopic morphology is needle-like, about 80nm in length.

Example Embodiment

[0026] Example 3

[0027] The first step is to add 9.54g of (CaNO 3 ) 2 · 4H 2 O was added to the pre-dissolved 80mL polyethylene glycol aqueous solution (4w%t).

[0028] The second step is to configure 0.8mol / L(NH 4 ) 2 HPO 4 The solution is 30mL, and the pH value is adjusted to 10 with ammonia water during the dripping process.

[0029] The third step is to continue stirring for 30 minutes and aging for 24 hours after the addition is completed.

[0030] The prepared nano-hydroxyapatite has a needle-like microstructure and a length of about 60 nm.

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Abstract

The invention provides a method for preparing rodlike nano hydroxyapatite. The method comprises the steps of weighing (CaNO3)2.4H2O and (NH4)2HPO4 powder, respectively dissolving the powder into water, dropwise adding the (NH4)2HPO4 solution into the (CaNO3)2.4H2O solution under the ultrasonic stirring condition, adding a dispersing agent, adjusting the pH value, aging, centrifuging, and washing the mixture with water to obtain the nano hydroxyapatite. The hydroxyapatite prepared by adopting the method can be well dispersed into a substrate without being specially treated, so that the defect that the agglomeration of the existing hydroxyapatite can be prevented by adding surface dispersing agent can be overcome. The method is simple, the high temperature and high pressure can be avoided, and the industrialized production can be favored.

Description

technical field [0001] The invention relates to a preparation method, more specifically, to a method for preparing nano-hydroxyapatite. Background technique [0002] At present, the production of nano-hydroxyapatite in the prior art is to first produce hydroxyapatite by precipitation method, sol-gel method or hydrothermal method, and then pulverize it to obtain nano-hydroxyapatite. However, after the precipitation method product is dried, it is easy to agglomerate, and the particle size is different, and the uniformity is poor, and it is often necessary to introduce a surface dispersant; the hydrothermal method requires extremely high reaction conditions (high temperature, high pressure), and the production equipment requires extremely high requirements. The cost is high, the safety is poor, and the output of the synthesized product is small, which is not conducive to industrial production; the sol-gel method is prone to agglomeration after calcination. Moreover, the produ...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y40/00B82Y30/00
Inventor 蒋庆全昌云刘珍珍苏蔷薇
Owner SUN YAT SEN UNIV
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