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High-strength double-network hydrogel/bioceramic composite stent and preparation method thereof

A technology of bioceramics and composite scaffolds, applied in bone implants, medical science, prostheses, etc., can solve problems such as unsuitable for use, and achieve the effect of ensuring stable connection, good mechanical properties and tribological properties

Active Publication Date: 2015-07-01
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in the process of preparing composite scaffolds, there is a problem of connecting soft materials with hard materials, namely double network hydrogels and bioceramics
The existing method is to connect them in a structural way, but due to the limitation of the water-containing characteristics of the double network hydrogel and its own forming method, this method is not suitable for use

Method used

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  • High-strength double-network hydrogel/bioceramic composite stent and preparation method thereof
  • High-strength double-network hydrogel/bioceramic composite stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1) Using CAD technology to design a model of the bioceramic scaffold 1 used as a part of the bone scaffold, and a negative mold for preparing the bioceramic scaffold 1, wherein the bioceramic scaffold 1 has a multi-channel structure through the length direction ; Ensure that the pipeline of the bioceramic stent is connected up and down, so as to facilitate the insertion of the connecting medium and the perfusion of the bonding medium in the subsequent steps. The height of the bioceramic stent 1 is 9 mm, the diameter is 8 mm, and the diameter of the through pipeline in the bioceramic stent is 1.2 mm. mm, the number of through pipes is 20. Simultaneously, the processing mold 5 for the double network hydrogel 2 used as the cartilage part is designed by computer aid, wherein the processing mold 5 is provided with a plurality of connecting media for connecting the bioceramic support and the double network hydrogel together 3, the connection medium 3 in this embodiment is pol...

Embodiment 2

[0044] 1) Using CAD technology to design a model of the bioceramic scaffold 1 used as a part of the bone scaffold, and a negative mold for preparing the bioceramic scaffold 1, wherein the bioceramic scaffold 1 has a multi-channel structure through the length direction ; Ensure that the pipeline of the bioceramic support is connected up and down, which is convenient for the insertion of the connection medium and the perfusion of the bonding medium in the subsequent steps. The height of the bioceramic support 1 is 10mm, the diameter is 10mm, and the diameter of the through pipeline in the bioceramic support is 1mm , the number of through pipes is 35. Simultaneously, the processing mold 5 for the double network hydrogel 2 used as the cartilage part is designed by computer aid, wherein the processing mold 5 is provided with a plurality of connecting media for connecting the bioceramic support and the double network hydrogel together 3, the connection medium 3 in this embodiment is...

Embodiment 3

[0050] 1) Using CAD technology to design a model of the bioceramic scaffold 1 used as a part of the bone scaffold, and a negative mold for preparing the bioceramic scaffold 1, wherein the bioceramic scaffold 1 has a multi-channel structure through the length direction ; Ensure that the pipeline of the bioceramic support is connected up and down, so as to facilitate the insertion of the connection medium and the perfusion of the bonding medium in the subsequent steps. The height of the bioceramic support 1 is 8 mm, the diameter is 9 mm, and the diameter of the through pipeline in the bioceramic support is 1.5 mm. mm, the number of through pipes is 28. Simultaneously, the processing mold 5 for the double network hydrogel 2 used as the cartilage part is designed by computer aid, wherein the processing mold 5 is provided with a plurality of connecting media for connecting the bioceramic support and the double network hydrogel together 3, the connecting medium 3 in this embodiment ...

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Abstract

The invention discloses a high-strength double-network hydrogel / bioceramic composite stent and a preparation method thereof. The high-strength double-network hydrogel / bioceramic composite stent uses double-network hydrogel as a cartilage part and uses a bioceramic stent provided with a penetrating duct in the length direction as a bone stent part. The preparation method comprises the following steps: inserting one end of a connecting medium into a first-layer hydrogel solution inside a processing mould, curing to obtain first-layer hydrogel, soaking the first-layer hydrogel in a second-layer hydrogel solution, taking out, and curing to obtain the double-network hydrogel which is fixed with one end of the connecting medium; inserting the other end of the connecting medium into the penetrating duct of the bioceramic stent, and fixing with a bonding medium to obtain the high-strength double-network hydrogel / bioceramic composite stent. The preparation method is simple; the connecting medium can ensure firm connection of soft and hard materials so as to prevent delamination of the double-network hydrogel on the bioceramic stent, as a result, a key problem of the connection of the soft and hard materials is solved; the prepared composite stent has relatively good mechanical and tribological properties.

Description

technical field [0001] The invention relates to a tissue engineering scaffold and a preparation method thereof, in particular to a high-strength double network hydrogel / biological ceramic composite scaffold and a preparation method thereof. Background technique [0002] There are about 3.5 million patients with bone defect or bone injury in China every year. The reason is that factors such as degeneration, trauma, and inflammation destroy the structure and function of articular cartilage and the underlying subchondral bone plate. According to the size of the defect area, it is divided into large-segment defect and small-segment defect. Since the development of tissue engineering, small osteochondral defects have been able to be effectively treated. But at present, the repair and treatment of large osteochondral defects is still an international problem in the medical field. [0003] The double network hydrogel has high mechanical properties and good biological properties, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/28A61L27/18B29C65/48
CPCA61F2/30756A61F2002/30001
Inventor 连芩李涤尘陈成陈咏梅夏显超贺健康刘亚雄靳忠民王玲
Owner XI AN JIAOTONG UNIV