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Preparation method of fluorescent nanoparticles for suppressing cancer cell

A fluorescent nanoparticle and nanoparticle technology, applied in the field of preparation of new fluorescent nanoparticles, can solve the problems of non-degradable aryl skeleton, toxicity and carcinogenicity, and achieve the effect of eliminating hidden dangers of toxicity and carcinogenicity

Inactive Publication Date: 2014-02-19
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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Problems solved by technology

However, conjugated polymers contain non-degradable aryl backbones and are potentially toxic and carcinogenic when used in vivo

Method used

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Experimental program
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Embodiment Construction

[0009] In order to deepen the understanding of the present invention, the present invention will be further described below in conjunction with specific examples.

[0010] (1) Synthesis of cationic polyester PIOT: 10mL of PIOT polymer (40mg, 0.063mmol) in N,N-dimethylformamide (DMF) solution was added to 2mL of N-methylimidazole, and the resulting solution was stirred at 60°C for 24h, Excessive N-methylimidazole in the solution was removed under vacuum drying, and the initial sample obtained was dissolved in 700 μL of methanol; the solution was slowly injected into 60 mL of methylene chloride, and the precipitate was separated by centrifugation, and centrifuged three times to obtain The sample was then dialyzed for three days with a membrane with a molecular weight cut-off of 8000Da to obtain a powdery product.

[0011] (2) Preparation of PIOT-HA nanoparticles: 4mL PIOT aqueous solution (350×10 -6 mol / L) and 400 μL hyaluronic acid (HA) aqueous solution (10×10 -3 mol / L) and t...

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Abstract

The invention relates to a preparation method of novel fluorescent nanoparticles. The novel fluorescent nanoparticles (PIOT-HA) are prepared by the interaction of cationic polyester (PIOT) and anionic hyaluronic acid (HA) in water solution, and can eliminate latent toxicity and carcinogenic risk while keeping fluorescence property of conjugated polymer. Under white light, the PIOT-HA nanoparticles can activate oxygen to generate reactive oxide species (ROS), which can deactivate CD44 proteins and effectively suppress metastasis of MDA-MB-231 cancer cells. Therefore, the PIOT-HA nanoparticles have good application prospect in cancer treatment.

Description

technical field [0001] The invention relates to a method for fluorescent nanoparticles, in particular to a method for preparing novel fluorescent nanoparticles that can be used to inhibit cancer cells. Background technique [0002] Cell invasion, the transfer of cells within tissues, plays a very important role in tissue repair, development and immune surveillance. However, in cancer cells, the metastasis of cells often becomes uncontrolled, leading to the invasion of malignant cells within tissues, blood vessels and lymph vessels, which will eventually lead to the spread and metastasis of the cancer from where it originated to other organs. Thus, 90% of cancer-related deaths are attributable to the spread and metastasis of cancer cells. Many molecular targeted medical technologies can inhibit the invasion and metastasis of cancer cells, but ineffective drug delivery and the resistance of cancer cells are the main obstacles to the treatment of cancer cell invasion and metas...

Claims

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Application Information

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IPC IPC(8): C09K11/06C08G63/91A61K31/728A61K47/34A61P35/04G01N21/64B82Y40/00B82Y30/00
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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