Method of preparing medical polypropylene monofilaments with improved biocompatibility

A technology of biocompatibility and polypropylene, applied in the field of preparing medical polypropylene monofilament with improved biocompatibility, can solve the problems of complicated process, increase cost, waste pearl powder, etc., and achieve the effect of excellent cell proliferation rate

Active Publication Date: 2014-03-12
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process is quite complicated, and the addition of additives other than pearl powder increases the cost to a certain extent
Because there is no kneading process, in the polypropylene fiber containing pearl powder prepared by the above method, a large amount of pearl powder exists inside the fiber, and relatively little exists on the surface of the fiber, which wastes pearl powder to a certain extent.
Moreover, the pearl powder and polypropylene fiber do not receive the pressure generated during the kneading process, and the force between the pearl powder and polypropylene molecules is small, which easily causes the pearl powder on the surface of the fiber to fall off.

Method used

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  • Method of preparing medical polypropylene monofilaments with improved biocompatibility
  • Method of preparing medical polypropylene monofilaments with improved biocompatibility
  • Method of preparing medical polypropylene monofilaments with improved biocompatibility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Melt Flow Index (MFI) 230℃ / 2.16kg 8g / 10min medical grade polypropylene pellets are used as raw materials. Each time, 2kg of polypropylene pellets and 30g of pearl powder (100nm in particle size) were put into the kneader for kneading. The kneaded mixed pellets (pearl powder content about 1.48%) are directly added into the spinning machine 1 for spinning. figure 1 It is the flow chart of blended monofilament spinning, which consists of melt spinning machine 1, machine head 2, cooling water tank 3, first drafting roll 4, hot drawing water tank 5, second drafting roll 6, air heat setting box 7. Winding device 8. It consists of eight major parts. In the spinning process, the raw materials pass through the melt spinning machine 1, and then enter the cooling water tank 3 through the spinneret. After stretching and winding, the required pearl powder modified polymer is obtained. Acrylic monofilament.

[0027] Kneading conditions

[0028] Kneading temperature: 50°C

[0029...

Embodiment 2

[0044] 2 kg of medical-grade polypropylene pellets with a melt index of 12g / 10min were mixed with pearl powder (400nm) of 80 to obtain blended pellets through a kneading mechanism. The kneading conditions

[0045]Kneading temperature: 80°C

[0046] Kneading speed: 30r / min

[0047] Kneading time: 2h

[0048] Spinning conditions

[0049] Screw zone 1-5 temperature: 210 / 230 / 240 / 250 / 255 / 260°C

[0050] Spinning assembly temperature: 260°C

[0051] Spinneret hole diameter: 3mm

[0052] Temperature of cooling water tank 3: 30°C

[0053] Hot stretching water tank 5 temperature 90°C

[0054] Stretch ratio: 7 times

[0055] Air heat setting box 7 Temperature: 140°C

[0056] Winding device 8 speed: 130m / min

[0057] Spun into a modified polypropylene monofilament with a pearl powder content of 4%.

[0058] Various performance tests show that the modified medical polypropylene monofilament has a fineness of 200dtex, a monofilament breaking strength of 4.5cN / dtex, and a breaking ...

Embodiment 3

[0062] Three batches of 2 kg of medical grade polypropylene pellets with a melt index of 16g / 10min were mixed with 20g, 60g, and 100g of pearl powder (1000nm) respectively to obtain blended pellets through a kneading mechanism. The kneading conditions

[0063] Kneading temperature: 100°C

[0064] Kneading speed: 10r / min

[0065] Kneading time: 3h

[0066] Spinning conditions

[0067] Screw zone 1-5 temperature: 210 / 230 / 240 / 240 / 245 / 250℃

[0068] Spinning assembly temperature: 250°C

[0069] Spinneret hole diameter: 3mm

[0070] Temperature of cooling water tank 3: 20°C

[0071] Hot stretching water tank 5 temperature 95°C

[0072] Stretch ratio: 7 times

[0073] Air heat setting box 7 Temperature: 140°C

[0074] Winding device 8 speed: 120m / min

[0075] Spun into three specifications of pearl powder modified polypropylene monofilament (about 1%, 3%, 5%).

[0076] The performance tests are shown in Table 1. Table 1 shows that the three kinds of modified medical polypro...

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Abstract

The invention relates to a method of preparing medical polypropylene monofilaments with improved biocompatibility and discloses a novel method of preparing medical polypropylene monofilaments with improved biocompatibility. The method comprises the following steps of: by adopting medical-level polypropylene slices and pearl powder as materials, fusing and extruding out monofilament fine flow by adopting a novel screw extruder after kneading by a kneading machine; winding and forming to obtain the modified polypropylene monofilaments containing pearl powder after water-bath cooling, solidifying, stretching and heat-setting. The monofilaments has diameters of 0.07 mm-0.20 mm, fineness of 35 dtex-300 dtex, breaking strength of 3.0 cN / dtex-5.0 cN / dtex and elongation at break of 15%-30%. The pearl powder content is 1%-5%, and cytotoxicity is graded as grade 0 through an MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method test. The product has good stability and uniformity, various mechanical performances reaching the level of the common medical-level polypropylene monofilaments, and biocompatibility superior to the common medical-level PP (Polypropylene) monofilaments.

Description

technical field [0001] The present invention relates to a method for preparing medical polypropylene monofilament with improved biocompatibility. Background technique [0002] With the continuous development of material science, more and more materials have entered the medical field as biomedical materials to repair defects in various parts of the human body, and medical patches and slings are one of them. At present, pure monofilament braided medical patches and slings have gained important applications in general surgery. It is mainly used for the repair of various hernias, female pelvic floor reconstruction and stress urinary incontinence. At present, the raw materials used as patches and slings include polypropylene, polyester, polytetrafluoroethylene, glycolic acid and the like. Among them, the most widely used is polypropylene monofilament. However, there are some problems in the application of polypropylene monofilament braided patches and slings, which will cause ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/46D01F1/10D01D5/098
Inventor 李光宋唯立金俊弘戴家木杨胜林江建明
Owner DONGHUA UNIV
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