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Laser scanning confocal microscope system

A technology of confocal microscopy and laser scanning, which is applied in the field of laser scanning confocal microscopy systems, can solve problems such as waste, system volume, increased complexity and cost, and the system cannot obtain confocal imaging results, etc., to achieve expansion and adaptation sexual effect

Active Publication Date: 2014-04-02
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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Problems solved by technology

[0004] At present, most commercial laser scanning confocal microscopes are equipped with fixed-wavelength lasers. It is difficult to add or adjust lasers. When carrying out some biomedical experiments, due to the mismatch between the fluorescent dye and the laser wavelength of the system, the system cannot work to good confocal imaging results
Configuring many kinds of lasers in the confocal microscope system seems to solve the problem, but this will bring other problems. On the one hand, the volume, complexity and cost of the system will increase a lot. On the other hand, for a specific user, some of them Lasers may be used sparingly, creating a lot of waste

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  • Laser scanning confocal microscope system

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Embodiment Construction

[0020] Please refer to figure 1 , figure 1 A schematic structural diagram 100 of a laser scanning confocal microscopy system provided by an embodiment of the present invention.

[0021] The laser scanning confocal microscope system 100 includes a laser unit 110, an acousto-optic modulator 120, a dichromatic mirror unit 130, an XY scanning galvanometer 140, a scanning lens 150, a tube lens 160, an objective lens 170, an imaging lens 180, a pinhole 190, Fluorescence detection unit 1110 and control unit 1120 .

[0022] Among them, the laser unit 110 includes a basic configuration laser unit 111 and an extended laser unit 112. The basic configuration laser unit 111 includes multiple lasers with different wavelengths and laser dichroic mirrors corresponding to the lasers respectively. The laser dichroic mirrors can reflect the corresponding lasers and Transmitting other laser light, the extended laser unit 112 is used to install the extended laser light and the laser dichroic mir...

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Abstract

The invention provides a laser scanning confocal microscope system. Due to configuration of laser of various wavelengths for a laser unit, the requirements on different lasers caused by various dyes are met, and the adaptability of the laser scanning confocal microscope system is improved, and meanwhile by adopting the laser unit, lasers can be flexibility configured according to demands of users, the basically configured lasers can be adjusted, also novel laser can be expanded, the system is simple, convenient and feasible, and the requirements on variable lasers caused by specific users are met.

Description

technical field [0001] The invention relates to the technical field of microscope optical detection, in particular to a laser scanning confocal microscope system. Background technique [0002] Laser Scanning Confocal Microscopy (LSCM) is an effective technical means and a necessary large-scale scientific instrument for studying microstructures, and has been widely used in the fields of biological and industrial detection. The system adopts precise pinhole filtering technology, so that only the information on the focal plane can be detected, and the stray light of the non-focus plane is suppressed to the greatest extent, and has high imaging resolution and signal-to-noise ratio; at the same time, the system along the Z The axial orientation enables non-destructive optical tomography, enabling 3D imaging of thicker samples. Laser scanning confocal microscopy for biomedical research in tissue biology, cell biology, molecular biology, genetics, embryology, neurology, pathology,...

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Application Information

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IPC IPC(8): G01N21/64
Inventor 张运海姜琛昱
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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