Cucurbitacin medicinal composition and pharmaceutical application thereof

A composition, the technology of cucurbitacin, which is applied in the field of cucurbitacin pharmaceutical composition and its pharmaceutical use, to achieve the effect of reducing toxicity, excellent stability and enhancing curative effect

Active Publication Date: 2014-04-23
DELI WEI BEIJING BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, micelles have been successfully used in the administration of water-insoluble drugs, showing high stability and biocompatibility in vivo and in vitro, but there is no report on the use of micelles to reduce the toxicity of cucurbitacin

Method used

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  • Cucurbitacin medicinal composition and pharmaceutical application thereof
  • Cucurbitacin medicinal composition and pharmaceutical application thereof
  • Cucurbitacin medicinal composition and pharmaceutical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the preparation of cucurbitacin B injection

[0032] prescription:

[0033]

[0034] Preparation method: Preheat sterilized water for injection at 70°C for later use; add the prescribed amount of F68 and cucurbitacin B into a beaker, stir at 70°C until completely dissolved, and continue stirring for 30 minutes; inject the same temperature under magnetic stirring Sterile water for injection (20 mg of calcium sodium EDTA is dissolved in it), stir until the system becomes a clear and transparent solution, then dilute to 1L with sterile water for injection, adjust the pH value to 6 with citric acid after mixing; add Appropriate amount of activated carbon, after stirring at room temperature for 30 minutes, filter to remove the activated carbon; pass through a 0.22 μm microporous membrane, dispense into 2 mL brown vials, 1 mL per bottle, fill with nitrogen, stopper, seal with an aluminum cap, sterilize at 121 ° C for 10 min, Instantly.

Embodiment 2

[0035] Embodiment 2: the preparation of cucurbitacin B injection

[0036] prescription:

[0037]

[0038] Preparation method: Weigh the prescribed amount of cucurbitacin B, polyethylene glycol 1000 lauryl hydroxystearate and stir evenly in a water bath at 70°C to form an oil phase; weigh the prescribed amount of F68, propylene glycol, ascorbic acid and part of water for injection Also heat to 70°C, after the substances in the two phases are completely dissolved, slowly add the water phase to the oil phase under stirring, continue stirring for 30 minutes, then dilute to 1L with water for injection, adjust the pH with sodium hydroxide after mixing value to 5; add an appropriate amount of activated carbon to it, stir at room temperature for 30 minutes, and filter to remove the activated carbon; pass through a 0.22 μm microporous membrane, dispense into 2 mL brown vials, each bottle is 1 mL, fill with nitrogen, stopper, and seal with an aluminum cap. Sterilize at 121°C for 10 ...

Embodiment 3

[0039] Embodiment 3: Preparation of cucurbitacin B freeze-dried preparation

[0040] prescription:

[0041]

[0042]

[0043] Preparation method: Weigh the prescribed amount of mannitol and EDTA calcium sodium, dissolve them completely at 70°C with 800mL sterile water for injection, preheat for later use, and obtain the aqueous phase; stir the prescribed amount of F68 and cucurbitacin B at 70°C until it is completely dissolved to obtain the oil phase; after the substances in the two phases are completely dissolved, slowly add the water phase to the oil phase under the condition of magnetic stirring, continue to stir for 30 minutes, dilute to 1L with sterile water for injection, mix well and use apple Adjust the pH value to 4.5 with acid; pass through a 0.22 μm microporous membrane, dispense into 3 mL brown vials, 1 mL each, freeze-dry, fill with nitrogen, stopper, and seal with an aluminum cap.

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PUM

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Abstract

The invention provides a cucurbitacin medicinal composition and pharmaceutical application thereof. The cucurbitacin medicinal composition comprises cucurbitacin, a solubilizer, an antioxidant and a pH regulator, wherein the using amount of the pH regulator is enough for regulating the pH value of the medicinal composition to 3.5-7.5; the weight ratio of the cucurbitacin to the solubilizer is (1:600)-(1:3,150). The medicinal composition can be used for preparing medicaments for lowering the toxicity of cucurbitacin as well as anti-hepatitis, jaundice-removing and anti-cancer medicaments.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a cucurbitacin pharmaceutical composition and its pharmaceutical application. Background technique [0002] Cancer refers to all malignant tumors and is one of the major diseases that seriously affect human health and threaten human life. According to the latest report of the International Cancer Research Center (IARC), the incidence of cancer is increasing at an average annual rate of 3-5%. It is estimated that by 2020, there will be 20 million new cancer cases and 12 million deaths worldwide. According to the latest data released by the Ministry of Health of my country in 2007, the first cause of death among urban and rural residents in China is malignant tumors, accounting for 1 / 4 of the death toll. Therefore, the World Health Organization and the health departments of governments of various countries have listed conquering cancer as a top priority. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P1/16A61P35/00
Inventor 邓吉林吴莹吴宝珍邓红玲
Owner DELI WEI BEIJING BIOLOGICAL TECH
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