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Refined traditional Chinese medicine composition for ginseng and astragalus yang warming vaginal expansion suppository as well as expansion suppository and preparation method thereof

A technique for vaginal expansive suppository and composition, which is applied in the field of refined traditional Chinese medicine composition, which can solve the problems of poor solubility of traditional Chinese medicine composition, large dosage of traditional Chinese medicine composition, and reduced bioavailability, so as to reduce side effects, improve stability, and improve dissolution degree of effect

Active Publication Date: 2014-04-23
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Shenqi Wenyang suppository has the effects of invigorating the spleen and kidney, warming the yang and stopping leukorrhea, and is used to improve the leukorrhagia caused by spleen and kidney deficiency in married women, such as excessive leucorrhea, thin color and white matter; The traditional Chinese medicine composition used to prepare Shenqi Wenyang suppository contains many ingredients that have not exerted curative effects. Compared with the amount of active ingredients that can improve the symptoms of gynecological diseases, the amount of active ingredients that improve the suppository should be increased. side effects; at the same time, because the dosage of the Chinese medicine composition is too large, it is unfavorable for the forming of the suppository;

Method used

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  • Refined traditional Chinese medicine composition for ginseng and astragalus yang warming vaginal expansion suppository as well as expansion suppository and preparation method thereof
  • Refined traditional Chinese medicine composition for ginseng and astragalus yang warming vaginal expansion suppository as well as expansion suppository and preparation method thereof
  • Refined traditional Chinese medicine composition for ginseng and astragalus yang warming vaginal expansion suppository as well as expansion suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]

[0035] Preparation:

[0036] a. Weigh the raw materials of ginseng, cnidium, astragalus, epimedium, motherwort, diapsis, saponins, cassia twig, aurantium aurantium, and licorice ten flavors in the prescribed amount, grind them, add 50% ethanol aqueous solution to reflux and extract three times, For the first time, the amount of ethanol added is 10 times of the total weight of the ten flavors of raw materials, refluxed for 3 hours, and the amount of ethanol added for the second time was 5 times of the total weight of the gross weight of the ten flavors of raw materials, refluxed for 2 hours, and the amount of ethanol added for the third time was ten times. 3 times the total weight of the raw material medicine, reflux for 1 hour, combine the reflux liquid, filter, and concentrate the filtrate to a thick paste with a temperature of 65 ° C and a relative density of 1.30;

[0037] b. Add the thick paste obtained in step a to 5 times the volume of water, stir fully, let...

Embodiment 2

[0040]

[0041] Preparation:

[0042] a. Weigh ginseng, cnidium fruit, astragalus, epimedium, motherwort, diapsis, saponins, cassia twig, citrus aurantium, licorice, genkwa and golden fruit olive twelve raw materials, pulverize, add 50% ethanol aqueous solution reflux extracts three times, first time adds ethanol amount and is 10 times of the total weight of twelve raw materials, refluxes 3 hours, adds ethanol amount for the second time and is 5 times of total weight of twelve raw materials, refluxes 2 hour, the amount of ethanol added for the third time is 3 times of the total weight of the twelve raw materials, reflux for 1 hour, merge the reflux liquid, filter, and the filtrate is concentrated to a thick paste with a temperature of 65 ° C and a relative density of 1.30;

[0043]b. Add the thick paste obtained in step a to 5 times the volume of water, stir fully, let it stand, recover the precipitate, dissolve the precipitate with ethanol, put it on a macroporous adsorpt...

Embodiment 3

[0046]

[0047] Preparation:

[0048] 1) Preparation of drug-containing matrix:

[0049] a. placing balsamic butter and glycerin gelatin in a water bath for heating and melting to obtain a melt;

[0050] b. Preparation of Chinese medicine composition: make the Chinese medicine composition of weight about 5g by the method for embodiment 1;

[0051] c. dissolving the Chinese medicine composition and polyethylene glycol monoacetate emulsifying wax in ethanol, and removing the solvent by spray drying to obtain a solid dispersion;

[0052] d. adding the solid dispersion to the melt in step a, and mixing uniformly to obtain a drug-containing matrix;

[0053] 2) Pour the drug-containing matrix into the suppository mold, insert the tampon, cool and shape, and make 100 spherical suppositories, each weighing about 1.8g.

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Abstract

The invention relates to a refined traditional Chinese medicine composition for a ginseng and astragalus yang warming vaginal expansion suppository as well as an expansion suppository and a preparation method thereof. Compared with the existing compositions used for preparing ginseng and astragalus yang warming suppositories, the content of the active ingredients of the traditional Chinese medicine composition is greatly increased; the curative effect of the traditional Chinese medicine composition after being prepared to the expansion suppository is improved as well, and meanwhile, daphne genkwa and radices tinosporae are added in the traditional Chinese medicine composition to improve the curative effect of the traditional Chinese medicine composition on vulvovaginal candidiasis; the traditional Chinese medicine composition and polyethylene glycol mono acetic ether emulsifying wax are made into a solid dispersoid, and coconut oil fatty acid diethanolamide, liquid paraffin and laurinol are added in the medicated matrix to further improve the bioavailability and stability of the expansion suppository.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a refined traditional Chinese medicine composition for Shenqi Wenyang vaginal expansive suppositories, an expansive suppository and a preparation method thereof. Background technique [0002] The State Drug Administration Trial Standard WS-5455 (B-0455)-2002 discloses the quality standard of Shenqi Wenyang suppository, which consists of ginseng 300g, cnidium 600g, astragalus 400g, epimedium 400g, motherwort 300g, diapsis 100g, It is prepared from 100g of saponins, 100g of cassia twigs, 100g of citrus aurantium, 300g of licorice and 1680g of semi-synthetic fatty acid glycerides. The Shenqi Wenyang suppository has the effects of invigorating the spleen and kidney, warming the yang and stopping leukorrhea, and is used to improve the leukorrhagia caused by spleen and kidney deficiency in married women, such as excessive leucorrhea, thin color and white matter; The traditional Ch...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K36/83A61K9/02A61K47/44A61K47/10A61P15/00A61P31/10
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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