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Intranasal medicinal composition containing bilastine and mometasone furoate

A technology of mometasone furoate and bilastine, which is applied in the directions of drug combinations, medical preparations containing active ingredients, non-active ingredients of polymer compounds, etc., can solve the problems of bilastine drops that are not reported in the literature. , to achieve the effect of improving medication compliance, excellent nasal sensation, and excellent stability

Inactive Publication Date: 2014-04-23
于运红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on bilastine drops and the method of masking its bitter taste

Method used

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  • Intranasal medicinal composition containing bilastine and mometasone furoate
  • Intranasal medicinal composition containing bilastine and mometasone furoate
  • Intranasal medicinal composition containing bilastine and mometasone furoate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 and 2

[0034] Embodiment 1 and 2: Suspension for nasal cavity spray

[0035] A nasal cavity spray suspension was prepared with the composition and content shown in Table 1 below. The contents in Table 1 represent w / v%.

[0036] Add microcrystalline cellulose RC591 and glycerin to sterile purified water, and disperse with a high-speed emulsifier (mixture 1). Add sterile purified water to other containers, and add bilastine, benzalkonium chloride, citric acid hydrate, sodium citrate hydrate, edetate sodium hydrate, D-sorbitol and thaumatin, Stirring was carried out to dissolve (mixture II). After adding sterilized purified water to another container, mometasone furoate and polysorbate 80 were added, followed by dispersion (Mixture III). After mixing and stirring the mixture I and the mixture II, it is mixed and stirred with the mixture III. Add sterile purified water to the resulting mixture to adjust the final volume.

[0037] Each specific embodiment component content of table 1...

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PUM

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Abstract

The invention provides an intranasal medicinal composition. The intranasal medicinal composition contains bilastine, mometasone furoate, and thaumatin serving as a bitterness and irritation alleviator.

Description

field of invention [0001] The present invention relates to a pharmaceutical composition for intranasal administration containing mometasone furoate and bilastine, in particular to a pharmaceutical composition for intranasal administration, which uses thaumatin to relieve bilastine The bitterness and irritation of the nose improves the nasal dripping feeling. Background of the invention [0002] Mometasone furoate, as a steroid drug for the treatment of allergic rhinitis, is known to have an excellent effect of continuously relieving symptoms, and bilastine, as a short-acting antihistamine, is known to have an excellent ability to immediately improve symptoms. Therefore, when these two drugs are administered as a combined preparation, it is expected to exhibit an excellent effect in the long-term treatment of allergic rhinitis while improving symptoms immediately. [0003] Bilastine is a highly selective histamine H1 receptor antagonist without sedative effect, which is used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K31/573A61K9/12A61P37/08A61K31/454
Inventor 于运红陈天丽王雅冬毛玉琳
Owner 于运红
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