Aripiprazole orally dissolving film and preparation method thereof

An aripiprazole and mouth-dissolving film technology is applied in the field of drug film preparations and their preparation, which can solve the problems of physical strength failing to meet the requirements for use, physical properties failing to meet the requirements, being easy to break, broken and the like, and to solve labor protection problems. and environmental pollution, excellent bioavailability, good stability
CN103784426BActive Publication Date: 2015-11-18SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
Publication Date
2015-11-18

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Abstract

The invention discloses an aripiprazole oral membrane and a preparation method thereof. The aripiprazole oral membrane contains cyclodextrin encapsulated aripiprazole, wherein the cyclodextrin is more than one of hydroxypropyl-beta-cyclodextrin and glucosyl-beta-cyclodextrin, and the weight ratio of the cyclodextrin to the aripiprazole is 1: 1 to 3: 1. The membrane preparation has the beneficial effects of even, smooth and clean membrane obtained, easy administration and direct administration without water, quick and safe dissolving-out, high absorption speed, high bioavailability, good curative effect, simple production process, low production cost, and high added value of products. The aripiprazole membrane is quick to dissolve out, good in stability and high in bioavailability, and excellent in bioavailability, and also good in compliance and popular with patients; the aripiprazole membrane is good in formability, and capable of directly adhering to the part to which the medicine is applied after administration, and thus cannot be spitted, and therefore, psychopaths can be prevented from spitting out and hiding the drug; and in the production process, almost no dust flies, and the problems of labor protection and environmental pollution can be solved.
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Description

technical field

[0001] The invention relates to an aripiprazole preparation, in particular to a drug film preparation and a preparation method thereof. Background technique

[0002] Aripiprazole belongs to the third generation of atypical antipsychotics, which has a significant effect on both positive and negative symptoms of schizophrenia, and has very few side effects. The existing marketed dosage forms are mainly ordinary tablets and orally disintegrating tablets. Because schizophrenic patients often take Tibetan medicine and vomit medicine when taking medicine, it greatly affects the curative effect of medicine. The film preparation does not need to be taken with water, it dissolves immediately on the tongue, and sticks there and is not easy to spit out, thus improving the compliance of clinical medication, especially suitable for mental patients; and the production process is simple, energy consumption is less, and the cost is relatively low. Low.

[0003] There have...

Claims

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