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Method for improving hydrophilicity of polypeptide membrane by using polylactic acid and polyacrylic acid

A polyacrylic acid and polylactic acid technology, which is applied in the field of polymer film preparation, can solve the problem of lack of hydrophilicity in the polypeptide film, and achieve the effects of improving the hydrophilicity of the polypeptide modified film, being easy to master and simple to operate.

Inactive Publication Date: 2014-05-21
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Polypeptide is a kind of biomaterial with biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the lack of good hydrophilicity of polypeptide film limits its application to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Synthesis of polypeptide-polylactic acid graft copolymer:

[0015] Add 12 grams of poly(r-benzyl-L-glutamate) with a molecular weight of 60,000, 3.1 grams of polylactic acid monotetradecyl ether with a molecular weight of 1000, and 0.9 grams of p-toluenesulfonic acid in the dry reactor, and then Add 260 ml of dimethyl sulfoxide solvent, under an inert atmosphere, stir and react at 55°C for 2 days, then terminate the reaction, and then obtain the target product by filtration, dialysis, and drying;

[0016] 2) Preparation of Polylactic Acid and Polyacrylic Acid Modified Polypeptide Film:

[0017] Add 10 grams of polypeptide-polylactic acid graft copolymer and 38.2 milliliters of dimethyl sulfoxide solvent into the dry reactor, and add polyacrylic acid (molecular weight: 4000) accounting for 2% of the total weight of the modified membrane. Under an inert atmosphere, After stirring and mixing at 45° C. for 40 minutes, a film was formed by casting method, and dried in a ...

Embodiment 2

[0020] 1) Synthesis of polypeptide-polylactic acid graft copolymer:

[0021] Add 12 grams of poly(r-ethyl-L-glutamate) with a molecular weight of 70,000, 5.3 grams of polylactic acid monotetradecyl ether with a molecular weight of 1500, and 0.91 grams of p-toluenesulfonic acid in the dry reactor, and then add 216 milliliters of dimethyl sulfoxide solvent, under an inert atmosphere, stirred and reacted at 56 ° C for 3 days, terminated the reaction, and then obtained the target product by filtration, dialysis, and drying;

[0022] 2) Preparation of Polylactic Acid and Polyacrylic Acid Modified Polypeptide Film:

[0023] Add 10 grams of polypeptide-polylactic acid graft copolymer and 36.5 milliliters of dimethyl sulfoxide solvent into the dry reactor, and add polyacrylic acid (molecular weight: 5000) accounting for 3% of the total weight of the modified membrane. Under an inert atmosphere, After stirring and mixing at 47° C. for 50 minutes, a film was formed by casting method, a...

Embodiment 3

[0026] 1) Synthesis of polypeptide-polylactic acid graft copolymer:

[0027] Add 12 grams of poly(r-methyl-L-glutamate) with a molecular weight of 80,000, 7.2 grams of polylactic acid monotetradecyl ether with a molecular weight of 2000, and 1.03 grams of p-toluenesulfonic acid in the dry reactor, and then add 177 milliliters of dimethyl sulfoxide, under an inert atmosphere, stirred and reacted at 57° C. for 3 days, terminated the reaction, and then obtained the target product by filtration, dialysis, and drying;

[0028] 2) Preparation of Polylactic Acid and Polyacrylic Acid Modified Polypeptide Film:

[0029] Add 10 grams of polypeptide-polylactic acid graft copolymer and 35.8 milliliters of dimethyl sulfoxide into the dry reactor, and add polyacrylic acid (molecular weight: 6000) accounting for 4% of the total weight of the modified membrane. After stirring and mixing at 50° C. for 60 minutes, a film was formed by casting method, and dried in a vacuum oven at 50° C. to obt...

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Abstract

The invention discloses a method for improving the hydrophilicity of a polypeptide membrane by using polylactic acid and polyacrylic acid. The method comprises the following steps: (1) the synthesis of a polypeptide-polylactic acid graft copolymer: adding a polypeptide homopolymer, polylactic-acid mono tetradecyl ether, a solvent and a catalyst into a dry reactor, and reacting for 2-3 days at the temperature of 55-57 DEG C in an inert atmosphere while stirring, filtrating, dialyzing and drying, so as to obtain the polypeptide-polylactic acid graft copolymer; (2) the preparation of a polylactic acid and polyacrylic acid modified polypeptide membrane: adding the polypeptide-polylactic acid graft copolymer, polyacrylic acid and a solvent into a dry reactor, stirring and mixing for 40-60 minutes at the temperature of 45-50 DEG C in an inert atmosphere, then, carrying out membrane forming by a tape casting method, and drying, thereby obtaining the target product of the method. According to the method, the preparation process is simple and is easy to grasp, and the hydrophilicity of the obtained modified membrane is improved greatly.

Description

Technical field [0001] The present invention involves a method of improving the hydrophilicity of polypeptide membranes, which belongs to the field of polymer film preparation technology. Background technique [0002] Polypeptide is a biological material with biocompatibility and biodegradable. The polypeptide membrane can be used as artificial skin, but the polypeptide membrane lacks good hydrophilicity, thereby limiting its application to a certain extent.Poly (d, L) lactic acid has good biocompatibility and degradable biodegradable, softened and has good coexistence with polyacrylic acid.Polyacryonic acid has good biocompatibility and degradable biodegradability, and has excellent hydrophilicity.First introduce the poly-lactic acid chain segment into a polypeptide chain segment to form a polypeptide-polystrack chief polymer to improve the coexistence of polypeptide, and then add the polyacrylic acid chain segment to the polypeptide-polymapilic acid binary segment to form a com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L87/00C08L33/02C08G81/00C08J5/18
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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