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Application of ergot sterone in phellinus igniarius to resisting H5N1 avian influenza virus

A kind of technology of Phylophorus spp. and ergosterone, applied in the direction of antiviral agents, applications, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2014-05-28
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ergosterone is a mild oxide of ergosterol, which has many important physiological activities such as antibacterial. Currently, no reports of anti-avian influenza virus activity have been reported

Method used

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  • Application of ergot sterone in phellinus igniarius to resisting H5N1 avian influenza virus
  • Application of ergot sterone in phellinus igniarius to resisting H5N1 avian influenza virus

Examples

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Effect test

example 1

[0032] The crude extract of Phylophorus chrysogenum is prepared by the following method:

[0033] (1) The fermentation medium formula is in grams / 100 milliliters:

[0034] Corn Starch 1% Glucose 1%

[0035] Peptone 0.1% Yeast Extract 0.1%

[0036] Magnesium sulfate 0.1% Potassium dihydrogen phosphate 0.01%

[0037] (2) Inoculate the Phyloporus spp. strains into the Erlenmeyer flask with the liquid medium in a conventional method, with a temperature of 25° C., a shaking flask rotation speed of 110 r / min, and pH 7 conditions, and vibrate for 7 days; cultivate When the pH value drops to 3, inoculate the seeds in the shake flask into the culture solution of a 50L fermenter, stir at a temperature of 25°C, a fermenter pressure of 0.1 kg / cm2, a pH of 3, and an air flow of 0.5-1.1vvm. Under the condition of a speed of 100 r / min, after culturing for 7 days, the crude extract of Pheronotus can be prepared by using the whole liquid fermented with the mycelia of Ph.

[0038] (3) Take ...

example 2

[0050] The crude extract of Phylophorus chrysogenum is prepared by the following method:

[0051] (1) The fermentation medium formula is in grams / 100 milliliters:

[0052] Corn Starch 3% Glucose 2%

[0053] Peptone 0.5% Yeast Extract 0.5%

[0054] Magnesium sulfate 0.5% Potassium dihydrogen phosphate 0.05%

[0055] (2) Inoculate the Phylophorus spp. strain into the Erlenmeyer flask with liquid medium in a conventional way, with a temperature of 30° C., a shaker flask rotation speed of 180 r / min, and pH 6 conditions, and vibrate for 15 days; during the cultivation When the pH value drops to 2.5, inoculate the seeds in the shake flask into the culture solution of a 50L fermenter, with a temperature of 30°C, a fermenter pressure of 0.2 kg / cm2, pH 3, an air flow of 0.5-1.1vvm, and a stirring speed Under the condition of 180 rev / min, after culturing for 15 days, the crude extract of Pheronotus can be prepared by using the fermented whole solution of Phyloporea mycelium.

[0056...

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Abstract

The invention discloses ergot sterone with an avian influenza-resisting activity, which is separated from fermentation broth and fruiting bodies of phellinus igniarius (LexFr) Quel (phellinus linteus (BerketCurt) Teng, phellinus baumii and phellinus hartigii (AlleschetSchnabl) Imaz). The invention firstly discloses a new activity of ergot sterone and proves that the ergot sterone has an avian influenza-resisting action. Compared with the application of a general compound, the method has the advantages that the special new activity of ergot sterone is found, and the ergot sterone has the action of resisting the avian influenza virus.

Description

technical field [0001] The present invention relates to a method for extracting and preparing active substances from Phylonotus spp., which is resistant to avian influenza H5N1 virus, especially the S. General Microbiology Center of the Preservation Management Committee", the deposit number is CGMCC No.8108, the taxonomic name is Phellinus igniarius, and the deposit address is No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences. Background technique [0002] Ergosterol is an important phytosterol (see Steroids), which is a steroid. Exist in yeast and ergot. CAS number: 57-87-4, molecular weight: 396.66, molecular formula C 28 h 44 O, relative density 1.04, melting point 168°C (crystal containing 1.5 moles of water) (166~183°C), boiling point 250°C. [0003] Ergosterone is a mild oxide of ergosterol, which has many important physiological activities such as antibacterial. So far, no reports of anti-avian i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P31/16C07J9/00A01G1/04
Inventor 赵晨宋爱荣孔超杨松秦丹
Owner QINGDAO AGRI UNIV
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