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Compound preparation for treating dermatophytoses of Asian elephants and preparation method thereof

A technology of dermatophytes and compound preparations, which is applied in the field of veterinary external medicines, can solve the problems of skin vitiligo, difficult diagnosis and treatment, and influence on the display and viewing effects of animals, and achieves the effects of high bacteriostatic effect and convenient use.

Inactive Publication Date: 2014-05-28
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this case, a sub-adult male elephant (Sissy) even had long-term skin diseases and other factors that affected its individual growth and development. Although it was 11 years old, it was still short in stature. Several other Asian elephants had white spots and cracks in their skin , itching, etc., which seriously affect the exhibition and viewing effects of animals
At the same time, due to their large size and ferocious nature, Asian elephants are not easy to access to treatment, which brings great difficulties to diagnosis and treatment.

Method used

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  • Compound preparation for treating dermatophytoses of Asian elephants and preparation method thereof

Examples

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Effect test

Embodiment 1

[0015] Example 1 In vitro model research for the treatment of compound preparations of Asian elephant dermatophytosis

[0016] The skin tissues of 3 Asian elephants with ulcers, inflammation, scabs and irregular shedding were collected, isolated, cultured, PCR amplified and sequenced for comparison, and it was found that it was a skin disease caused by Microsporum spp. The in vitro susceptibility test adopts the antifungal susceptibility test protocol M38-A published by the American Clinical and Laboratory Standards Institute (LSI) against griseofulvin, fluconazole, amphotericin, mugwort essential oil, and terbinafine The chemical drugs and the extracts of the three natural medicines of Artemisia argyi essential oil, allicin and artemisinin were tested. The results show that in the in vitro susceptibility test, the antibacterial effect of chemical drugs is far superior to that of natural drug extracts. Terbinafine has the best antibacterial effect in chemical drugs, and the mi...

Embodiment 2

[0028] Example 2 Animal use research

[0029] Asian elephants suffered from skin diseases in Chongqing Zoo for many years. From 2000 to 2008, they were treated with western medicines such as potassium permanganate, bactobang, dactracin, terbinafine hydrochloride gel, and dermatitis. A sub-adult Asian elephant "Sissy" (12 years old) even developed scalp itching, which caused a 12-16×10-14cm wound on the forehead when rubbed against the iron bars, and the other two adult elephants also developed severe Itching and skin white spots, cracking and other symptoms. For this reason, at the beginning of 2008, the affected area was washed with Artemisia argyi essential oil, twice a week for 5 consecutive weeks. After taking the medicine, "Sissy"'s scalp abrasions healed, and the skin cracks disappeared. The other two adult Asian elephants' symptoms of itching, white spots, and cracks disappeared. Good results were achieved, but they only lasted for 2 months and relapsed. From 2009 to ...

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Abstract

The invention provides a compound preparation for treating dermatophytoses of Asian elephants. The compound medicament comprises an active ingredient, namely a mixture of terbinafine hydrochloride, and artemisia vulgaris oil. Compared with the existing single-formula antifungal drug, the compound medicament provided by the invention has a better antibacterial effect, and more importantly, the compound medicament provided by the invention can be directly smeared on the elephants by using a simple tool after being diluted, so that the compound medicament is very convenient in use.

Description

technical field [0001] The invention relates to a veterinary medicine for external use, in particular to a compound preparation for treating dermatophytosis of Asian elephants and a preparation method thereof. technical background [0002] Asian elephant (also known as elephant) scientific name Elephas maximus, English name: Indian Elephant, distributed in southern Yunnan Province, China. It is found abroad in South Asia and Southeast Asia. Live in tropical forests, jungles or grasslands, live in groups, led by a female elephant, have no fixed habitat, daily behavior, poor vision (mainly because the elephant's eyelashes are relatively long, which affects vision), sensitive sense of smell and hearing, hot It likes to bathe in water, and forages in the morning and evening. It feeds on weeds, leaves, bamboo leaves, wild fruits, etc. It is a Chinese-level protected animal and is included in the Convention on International Trade in Endangered Species of Wild Fauna and Flora. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61K9/08A61P17/00A61P31/10A61K31/137
Inventor 樵星芳杨金龙杨扬吴登虎杨松全殷素会陈建康米本中
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA