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Method for extracting medication composition from amorpha fruticosa root and novel medical application

The technology of Amorpha fruticosa and its composition is applied in the preparation of α-glucosidase inhibitor drugs and lipase inhibitor drugs. The pharmaceutical preparation field of the drug can solve the problem that there is no pharmaceutical composition to inhibit α-glucosidase Activity and inhibition of lipase activity and other issues

Inactive Publication Date: 2014-05-28
JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention is a pharmaceutical composition extracted from the root of Amorpha fruticosa root. Before the completion of the present invention, there was no literature report about the preparation method and medical application of the composition extracted from the root of Amorpha fruticosa root, let alone the pharmaceutical composition of the present invention. The report that the compound has the activity of inhibiting α-glucosidase and inhibiting the activity of lipase

Method used

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  • Method for extracting medication composition from amorpha fruticosa root and novel medical application
  • Method for extracting medication composition from amorpha fruticosa root and novel medical application
  • Method for extracting medication composition from amorpha fruticosa root and novel medical application

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example 1

[0048] The preparation method of example 1 amorpha root medicinal composition

[0049] Amorpha root 10kg, sliced, soaked in deionized water at 60°C for 3 times with 6 times the amount, 3 hours each time, filtered, and refluxed the filter residue with 75% ethanol with 6 times the weight of the medicinal material for 2 times, 3 times each time hours, filtered, the filtrate passed through the treated macroporous resin column, and then eluted with 75% ethanol for 5 times the column volume, collected the effluent and eluent, recovered the ethanol, concentrated, centrifuged, precipitated and dried to obtain Aurantia chinensis Sophora root medicinal composition 415g, total flavonoid content is 89.6%.

example 2

[0050] The preparation method of example 2 amorpha root medicinal composition

[0051] Amorpha root 10kg, sliced, first soaked 3 times with 8 times the amount of 50 ℃ deionized water, 4 hours each time, filtered, and the filter residue was extracted 3 times with 85% ethanol with 8 times the amount of the weight of the medicinal material, 2 times each time hours, filtered, the filtrate passed through the treated macroporous resin column, and then eluted with 85% ethanol for 5 times the column volume, collected the effluent and eluent, recovered the ethanol, concentrated, centrifuged, precipitated and dried to obtain Aurantia chinensis Sophora root medicinal composition 442g, total flavonoid content is 82.9%.

[0052]

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Abstract

The invention provides a medication composition ,which contains isopentenyl biflavone and isoflavone and is extracted and separated from the novel medicinal resource amorpha fruticosa root for the first time, and that the amorpha fruticosa root medication composition has the effects of inhibiting alpha-glucosidase activity and lipase activity, and can be used for preventing and treating diabetes and hyperlipemia is proved for the first time. The invention further relates to a pharmaceutical preparation of the medication, and the medication can be prepared into oral preparations such as hard capsule, soft capsule, tablet, granule, powder, pill, tea-bag and medicated wine.

Description

technical field [0001] The present invention relates to a method for preparing a pharmaceutical composition extracted from the root of Amorpha fruticosa root and the application of the pharmaceutical composition in the preparation of α-glucosidase inhibitor drugs and lipase inhibitor drugs, which can be used for preventing and treating diabetes and hyperlipidemia The role of blood lipids. The invention also relates to the pharmaceutical preparation of the medicine, which belongs to the technical field of medicine. Background technique [0002] Diabetes and hyperlipidemia are both metabolic diseases, and diabetes is often accompanied by lipid metabolism disorders and hyperlipidemia. At present, the incidence of metabolic diseases is getting higher and higher, which can involve chronic progressive lesions in the heart, brain, kidney, lung, blood vessels, nerves, skin, eyes, ears, feet and other tissues, causing functional defects and failure, which has become serious. Threat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P3/10A61P3/06A61K125/00
Inventor 南敏伦赵昱玮赫玉芳常艳茹吕娜任颖慧
Owner JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
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