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Application of peanut root extract in preparing medicine or food for preventing and treating prostatic hyperplasia

A technique for benign prostatic hyperplasia and peanut root, which is applied in the field of medicine to achieve the effect of less side effects and rich sources of raw materials

Inactive Publication Date: 2018-02-09
LUOHE MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is a folk saying that "single prescription" peanut root traditional Chinese medicine, peanut root has its own effect of tonifying deficiency, but it is still not reported that it is used in the preparation of drugs or food for the prevention and treatment of benign prostatic hyperplasia

Method used

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  • Application of peanut root extract in preparing medicine or food for preventing and treating prostatic hyperplasia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Preparation of peanut root extract liquid

[0017] Step A: collect the fresh peanut roots discarded in the field, wash and dry them;

[0018] Step B: take 500 g of peanut root powder in step A, dissolve it with 1000 ml of ethanol with a volume fraction of 60% as an extractant, and boil and reflux for 30 minutes;

[0019] Step C: Cool the product obtained in Step B to 20°C for suction filtration, and take the filtrate;

[0020] Step D: Distill the product obtained in Step C under reduced pressure to obtain a concentrate;

[0021] Step E: Dissolve the product obtained in Step D with 50 ml of double distilled water to obtain a pharmaceutical grade liquid.

[0022] The obtained medicinal liquid of peanut root extract is equivalent to 10 g / ml of crude drug.

Embodiment 2

[0023] Embodiment 2: pharmacological test

[0024] experiment material:

[0025] 1. Animals:

[0026] Male SD rats, weighing 180-200 g, free from specific pathogens, were provided by the Animal Center of Jiangxi University of Traditional Chinese Medicine.

[0027] 2. Drugs and reagents:

[0028] The peanut root extract medicinal solution prepared in Example 1, Testosterone Propionate Injection (TP) 25 mg / ml, is produced by Shanghai General Pharmaceutical Co., Ltd.

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Abstract

The invention relates to the technical field of medicine and food, in particular to the application of peanut root extracts in the preparation of medicines or foods for preventing and treating prostatic hyperplasia, and the preparation method of peanut root extract medicinal liquid: firstly, the peanut roots are washed, dried and powdered, and then used The extract is dissolved, boiled and refluxed, then cooled and filtered, the filtrate is concentrated, and finally the concentrate is dissolved in double distilled water to make it reach the pharmaceutical grade. The present invention has passed the SD rat test to verify that the peanut root extract that reaches a certain dose The drug liquid can effectively reduce the prostate index and inhibit the hyperplasia of the prostate gland. The invention provides a new source of medicine for the prevention and treatment of the hyperplasia of the prostate gland, which may be developed into a peanut root with high curative effect and small side effects, and expands the application range of the peanut root , and because peanuts are basically crops, they have little side effects on the human body, have the advantages of being widely planted and rich in sources, and will have good economic and social benefits for the planting of peanuts and increasing farmers' income.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of peanut root extract in preparing medicine or food for preventing and treating prostatic hyperplasia. Background technique [0002] Benign prostatic hyperplasia (BPH) is a common and frequently-occurring disease in elderly men. With the aging of the global population, its incidence is increasing. To date, the pathogenesis of BPH is not fully understood. Some studies suggest that the occurrence of BPH is not only related to the abnormal expression of proliferation genes, apoptosis genes and anti-apoptosis genes, but also probably related to the imbalance of androgen and estrogen and the interaction of various growth factors. The high expression of anti-apoptotic gene bcl-2 after the decline of androgen level in the elderly leads to the decrease of prostate cell apoptosis, which may be the main factor for the occurrence of BPH. [0003] At present, surgical tre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P13/08A23L33/00
Inventor 马永超郭小慧陈红莲卑占宇罗晓冰王敏赵丽芳陈永芳
Owner LUOHE MEDICAL COLLEGE