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Application of traditional Chinese medicine composition in preparation of drug for inhibiting rheumatoid arthritis angiogenesis

An angiogenesis and rheumatoid technology, applied in drug combinations, plant/algae/fungus/moss components, cardiovascular system diseases, etc., can solve problems such as lack of structural integrity, cancer cell metastasis, high pressure between tissues, etc., to achieve Preventing the increase and shedding of arterial plaques, inhibiting FAK phosphorylation, and inhibiting angiogenesis

Active Publication Date: 2014-06-04
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Compared with normal blood vessels, the structure of tumor blood vessels lacks integrity, there are large gaps between endothelial cells, strong permeability, disordered vascular network structure, a large number of vascular blind ends and arteriovenous short circuits, abnormalities of this structure Lead to increased exudation and high pressure between tissues, and also prone to cancer cell metastasis

Method used

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  • Application of traditional Chinese medicine composition in preparation of drug for inhibiting rheumatoid arthritis angiogenesis
  • Application of traditional Chinese medicine composition in preparation of drug for inhibiting rheumatoid arthritis angiogenesis
  • Application of traditional Chinese medicine composition in preparation of drug for inhibiting rheumatoid arthritis angiogenesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The raw material formula is :

[0064] Astragalus 250g, Ligustrum lucidum 200g, Ginseng 65g, Ganoderma lucidum 65g, Curcuma 132g, Stir-fried Atractylodes macrocephala 64g, Banzhilian 128g, Gynostemma pentaphyllum 256g, Poria cocos 65g, Gallus chinensis 30g, Snakeberry 128g, Baiying 128g, Yinchen 128g, Xu Changqing 128g, ground beetle 20g, Hedyotis diffusa 128g.

[0065] The preparation method is :

[0066] (1), take the Chinese medicinal material according to the weight ratio of the crude drug, and select it;

[0067] (2) For ginseng and Ligustrum lucidum, add 8 times the amount of 70% ethanol for reflux extraction twice, the first time for 3 hours, and the second time for 2 hours, combine the extracts, recover the ethanol until there is no alcohol smell, and the filtrate and ginseng, female Sadako residue for use;

[0068] (3) Combine and extract the volatile oil from Curcuma, Stir-fried Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes Rhizoma Atractylodes...

Embodiment 2

[0074] The raw material formula is :

[0075] Astragalus 360g, Ligustrum lucidum 100g, Ginseng 95g, Ganoderma lucidum 30g, Curcuma 195g, Stir-fried Atractylodes macrocephala 30g, Scutellaria barbata 195g, Jiaogulan 120g, Poria cocos 95g, Gallus gallis 15g, Snakeberry 195g, Baiying 65g, Yinchen 195g, Xu Changqing 65g, ground beetle 30g, Hedyotis diffusa 65g.

[0076] The preparation method is :

[0077] (1), take the Chinese medicinal material according to the weight ratio of the crude drug, and select it;

[0078] (2), ginseng, Ligustrum lucidum, add 6 times the amount of 90% ethanol to reflux and extract for 4 hours, recover the ethanol from the extract until there is no alcohol smell, and the filtrate and ginseng, Ligustrum lucidum residues are for subsequent use;

[0079] (3) Combine Curcuma, Stir-fried Atractylodes Rhizoma Atractylodes Rhizome and Xu Changqing, add 4 times the amount of water to extract the volatile oil, the oil extraction time is 10 hours, collect...

Embodiment 3

[0085] The raw material formula is :

[0086] Astragalus 120g, Ligustrum lucidum 300g, Ginseng 30g, Ganoderma lucidum 95g, Curcuma 65g, Atractylodes macrocephala 90g, Scutellaria barbata 65g, Jiaogulan 360g, Poria cocos 30g, Gallus gallus 45g, Snakeberry 65g, Baiying 195g, Yinchen 65g, Xu Changqing 195g , Wood Beetle 10g, Hedyotis diffusa 195g.

[0087] The preparation method is :

[0088] (1), take the Chinese medicinal material according to the weight ratio of the crude drug, and select it;

[0089] (2) For ginseng and Ligustrum lucidum, add 10 times the amount of 50% ethanol to reflux and extract twice, the first time for 3 hours, and the second time for 2 hours, combine the extracts, recover the ethanol until there is no alcohol smell, and the filtrate and ginseng, female Residues of chastity seeds for use;

[0090] (3) Merge Curcuma, Atractylodes Rhizoma Atractylodes Rhizome, and Xu Changqing, add 10 times the amount of water to extract the volatile oil, the oi...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparation of drugs for inhibiting rheumatoid arthritis angiogenesis. The traditional Chinese medicine composition comprises traditional Chinese medicines such as radix astragali, ligustrum lucidum and the like. The traditional Chinese medicine composition has the effects of tonifying qi and nourishing yin, invigorating spleen and tonifying kidney, dissipating binds and dredging collaterals, and focuses on the pathogenesis; experiments confirm that the traditional Chinese medicine composition of the invention can effectively inhibit angiogenesis, and can be clinically used for rheumatoid arthritis. The traditional Chinese medicine composition of the invention is reasonable in combination, has less adverse drug reaction, and is suitable for long-term use by patients.

Description

[0001] The patent application for this invention is a divisional application, and the original information is as follows: [0002] Application number: 201210166200.5 [0003] Application date: May 26, 2012 [0004] Title of the invention: Application of a traditional Chinese medicine composition in the preparation of drugs for inhibiting angiogenesis. technical field [0005] The invention relates to a new application of a traditional Chinese medicine composition, in particular to the application of a traditional Chinese medicine composition in the preparation of drugs for inhibiting angiogenesis, which belongs to the field of traditional Chinese medicine applications. Background technique [0006] Angiogenesis (i.e., new blood vessel formation) includes angiogenesis and angiogenesis; angiogenesis refers to the formation of new blood vessels by sprouting from existing blood vessels, and angiogenesis refers to the recruitment of angioblasts / endothelial progenitor cells to th...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P35/00A61P29/00A61P9/10A61P9/00A61K35/37A61K35/64A61K35/57
Inventor 魏聪王宏涛张会欣常丽萍肖维刚安军永
Owner SHIJIAZHUANG YILING PHARMA
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