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Extraction process of ephedrine

An extraction process, ephedrine technology, applied in the field of extraction of active ingredients in traditional Chinese medicine, can solve the problems of cumbersome process, high cost, inability to efficiently extract ephedrine, etc., achieve smooth process, good extraction effect, increase extraction rate and purification effect Effect

Inactive Publication Date: 2014-06-04
杨超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the problem that ephedrine cannot be efficiently extracted in the above-mentioned prior art, and the process is cumbersome and the cost is high, and provides an extraction process for ephedrine, which can quickly and effectively extract ephedrine in ephedra

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of extraction technology of ephedrine, comprises following processing steps:

[0030] A. Ephedra pretreatment

[0031] Drying the ephedra, removing impurities and pulverizing to obtain ephedra powder;

[0032] B. Alkalinization

[0033] Soak the ephedra powder in saturated sodium hydroxide for 1 hour and filter to obtain the alkalized ephedra powder;

[0034] C. Xylene extraction

[0035] Add xylene to the alkalized ephedra powder obtained in step B, the mass volume ratio of the alkalized ephedra powder to xylene is 1:2, heat to reflux, and extract twice to obtain a xylene extract;

[0036] D. Extraction

[0037] Add 2% oxalic acid to the xylene extract, mix, and heat in a water bath at 50°C at the same time to obtain an oxalic acid extract;

[0038] E. Concentration

[0039] The oxalic acid extract obtained in step D was concentrated under reduced pressure, cooled and crystallized to obtain a solid extract of ephedrine.

Embodiment 2

[0041] A kind of extraction technology of ephedrine, comprises following processing steps:

[0042] A. Ephedra pretreatment

[0043] Drying the ephedra, removing impurities and pulverizing to obtain ephedra powder;

[0044] B. Alkalinization

[0045] Soak the ephedra powder in saturated sodium hydroxide for 3 hours and filter to obtain the alkalized ephedra powder;

[0046] C. Xylene extraction

[0047] Add xylene to the alkalized ephedra powder obtained in step B, the mass volume ratio of the alkalized ephedra powder to xylene is 1:5, heat to reflux, and extract 3 times to obtain a xylene extract;

[0048] D. Extraction

[0049] Add 2% oxalic acid to the xylene extract, mix, and heat in a water bath at 80°C at the same time to obtain an oxalic acid extract;

[0050] E. Concentration

[0051] The oxalic acid extract obtained in step D was concentrated under reduced pressure, cooled and crystallized to obtain a solid extract of ephedrine.

Embodiment 3

[0053] A kind of extraction technology of ephedrine, comprises following processing steps:

[0054] A. Ephedra pretreatment

[0055] Drying the ephedra, removing impurities and pulverizing to obtain ephedra powder;

[0056] B. Alkalinization

[0057] Soak the ephedra powder in saturated sodium hydroxide for 2 hours and filter to obtain the alkalized ephedra powder;

[0058] C. Xylene extraction

[0059] Add xylene to the alkalized ephedra powder obtained in step B, the mass volume ratio of the alkalized ephedra powder to xylene is 1:3.5, heat to reflux, and extract 3 times to obtain a xylene extract;

[0060] D. Extraction

[0061] Add 2% oxalic acid to the xylene extract, mix, and heat in a water bath at 65°C at the same time to obtain an oxalic acid extract;

[0062] E. Concentration

[0063] The oxalic acid extract obtained in step D was concentrated under reduced pressure, cooled and crystallized to obtain a solid extract of ephedrine.

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Abstract

The invention relates to an extraction process of ephedrine, and belongs to the technical field of extraction of effective components in traditional Chinese medicines. The process provided by the invention comprises the following steps: pretreatment of ephedra; alkalization; extraction with xylene; extraction; concentration; and the like. By adopting the processes such as alkalization, extraction with xylene and extraction with oxalic acid, tedious processes in the prior art can be simplified, and high purity ephedrine can be quickly and effectively extracted.

Description

Technical field [0001] The present invention relates to an extraction process of active ingredients in traditional Chinese medicines. More specifically, the present invention relates to an extraction process of ephedrine, which belongs to the technical field of extracting active ingredients in traditional Chinese medicines. Background technique [0002] Ephedra is a Chinese medicine or a medicine for dispersing wind and cold; in ancient times, it was also known as Longsha and Beixiang. There are three species of Ephedra: Ephedra sinica, Ephedra equisetina and Ephedra intermedia. The parts used are herbaceous stems. Ephedra ephedra is a small shrub, often herbaceous, with a stem height of 20-40 cm. There are few branches, the woody stem is short and creeping; the branchlets are round, opposite or whorled, with internodes 2.5-6 cm long and about 2 mm in diameter. [0003] The main active ingredients in ephedra are alkaloids, such as ephedrine hydrochloride, pseudoephedrine h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C215/30C07C213/10
Inventor 杨超
Owner 杨超
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