Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage

A technology of cells and substances applied in the field of compositions and methods of non-genetically modified reprogrammed cells for repairing cartilage damage
CN103857797AInactive Publication Date: 2014-06-11VIVOSCRIPT +1
4 Cites 9 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
VIVOSCRIPT
Publication Date
2014-06-11
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), MSCs, fibroblasts, hematopoietic stem cells, endothelian stem cells, adipocytes, chondrocytes, osteoblasts, osteoclasts and endothelial cells) into chondrogenic cells without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
Need to check novelty before this filing date? Find Prior Art

Description

[0001] priority statement

[0002] This application claims priority to the following US Provisional Patent Application: US Provisional Patent Application 61 / 509,114, filed July 19, 2011, which is hereby incorporated by reference in its entirety. Background of the invention

[0003] Embryonic stem cells are capable of differentiating into many types of human cells. Most somatic cells are terminally differentiated cells and are thought to lack the ability to transform into other types of somatic cells. Recent advances in the field of induced pluripotent stem cells (iPSCs) and transdifferentiation have changed this paradigm. Ectopic expression of four transcription factors, Oct4 (e.g., SEQ ID NO:1), Sox2 (e.g., SEQ ID NO:2), Klf4 (e.g., SEQ ID NO:3), and cMyc (e.g., SEQ ID NO:4) by viral transduction , somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) (Okita et al., Nature 448, 313-317 (2007); Takahashi and Yamanaka, Cell 126, 663-676 (2006)). A num...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More