Compound Jiangya Capsules for Auxiliary Treatment of Refractory Hypertension and Its Preparation and Application

An adjuvant therapy and refractory technology, applied in the direction of capsule delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as hypertension, achieve the effects of regulating blood pressure, protecting vascular structure, and improving vascular elasticity

Inactive Publication Date: 2016-05-11
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is difficult to obtain further curative effect in the treatment of refractory hypertension by western medicine

Method used

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  • Compound Jiangya Capsules for Auxiliary Treatment of Refractory Hypertension and Its Preparation and Application
  • Compound Jiangya Capsules for Auxiliary Treatment of Refractory Hypertension and Its Preparation and Application
  • Compound Jiangya Capsules for Auxiliary Treatment of Refractory Hypertension and Its Preparation and Application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of the original drug: Take 40g of Apocynum baicalensis, 20g of wild chrysanthemum, 10g of Morus alba, 10g of Sophora japonica, 10g of Prunella vulgaris, and 10g of starch auxiliary material according to the prescription.

[0045] Preparation method embodiment one

[0046] (1) Extract volatile oil: soak 20g of wild chrysanthemum flower with a small amount of water for 0.5h, then continue to add 100g of water, and extract volatile oil a by steam distillation for 3.5h;

[0047] Collect volatile oil a and filter residues b and filtrate c for subsequent use;

[0048] (2) Alcohol extraction: take the medicinal residue b generated in step (1) and carry out three alcohol extractions: the first alcohol extraction: add 180 g of 85% ethanol to the medicinal residue b remaining after the volatile oil extraction process of the wild chrysanthemum, Use ethanol as an auxiliary agent for extraction, the extraction time is 1.5h, and the extract is ready for use. The second a...

Embodiment 2

[0053] Preparation of original medicine: Take 45g of Apocynum apocynum according to the prescription, 22g of wild chrysanthemum, 12g of Morus alba, 12g of Sophora japonica, 12g of Prunella vulgaris, 15g of starch auxiliary material

Embodiment 2

[0055] (1) Extract volatile oil: soak 22g of wild chrysanthemum flower with a small amount of water for 1 hour, then continue to add 132g of water, and extract volatile oil a by steam distillation for 4.5 hours;

[0056] Collect volatile oil a and filter residues b and filtrate c for subsequent use;

[0057] (2) Alcohol extraction: take the medicinal residue b generated in step (1) and carry out three alcohol extractions: the first alcohol extraction: add 220 g of 85% ethanol to the medicinal residue b remaining after the volatile oil extraction process of the wild chrysanthemum, Use ethanol as an auxiliary agent for extraction, the extraction time is 2 hours, and the extract is ready for use. The second alcohol extraction: add 176g of 85% ethanol to the dregs produced by the first alcohol extraction, and use ethanol as an auxiliary agent for secondary extraction. The time is 1.5h, the extract is for use, and the third alcohol extraction: add 154g of 85% ethanol to the dregs p...

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Abstract

A compound Jiangya capsule for auxiliary treatment of refractory hypertension and its preparation and application, is a preparation process of compound Jiangya capsule for the treatment of hypertension with hyperactivity of liver yang and internal stasis of water, composed of wild chrysanthemum The mixed solution obtained by adding the alcohol extract of medicinal dregs produced after the volatile oil extraction process, the combined water extract of Apocynum apocynum, Morus alba, Sophora japonica, and Prunella vulgaris to the filtrate produced by filtering medicinal dregs in the process of extracting volatile oil from wild chrysanthemum, The alcohol extract and the mixed solution are concentrated, dried and pulverized to obtain two kinds of dry paste powders, mixed with auxiliary material starch to make granules, and then sprayed with volatile oil extracted from wild chrysanthemum and mixed evenly. The compound antihypertensive capsule prepared by the preparation process of the invention can assist western medicine in treating refractory hypertension, regulate blood pressure, protect hypertensive blood vessel remodeling and prevent kidney and other target organ damage.

Description

technical field [0001] The invention relates to a Chinese patent medicine and its preparation and application, in particular to a compound antihypertensive capsule for auxiliary treatment of refractory hypertension and its preparation and application. Background technique [0002] Refractory hypertension (RH) is a special type of hypertension in front of all clinicians, often accompanied by severe target organ damage, and the risk of heart failure, stroke, myocardial infarction, and renal insufficiency increases in patients , the prognosis is poor. According to statistics, it is found that resistant hypertension accounts for 12% to 15% of the incidence of clinical hypertension, and with the aging of the population and the increase in the incidence of obesity, resistant hypertension tends to gradually increase. Therefore, how to make the blood pressure level of the patients with refractory hypertension reach the target is of great significance to improve the condition of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605A61K9/48A61P9/12
Inventor 李晓晖袁洪李莹阳国平李顺祥
Owner CENT SOUTH UNIV
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