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Pharmaceutical composition containing capecitabine and used for treating stomach cancer

A technology of capecitabine and its composition, which is applied in the field of pharmaceutical preparations, can solve problems such as irritation, gastrointestinal bleeding and bone marrow suppression, and achieve the effects of reducing the amount of treatment, reducing side effects and improving the therapeutic effect

Inactive Publication Date: 2014-06-25
宋婷婷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although capecitabine is effective, it has adverse reactions similar to 5-FU, which can cause nausea, vomiting, diarrhea, gastrointestinal irritation, gastrointestinal bleeding and bone marrow suppression, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0021] The preparation of embodiment 1-3 pharmaceutical composition

[0022] The molar ratio of Example 1 Example 2 Example 3 Capecitabine 10 20 15 Oleuropein 6 9 7 Glycyrrhizin 4 6 5

[0023] Mix the above three compounds according to the molar ratio in the table to obtain the pharmaceutical composition of the present invention.

[0024]

Embodiment 4

[0026] Human gastric cancer cell BGC-823 was cultured in RPMI1640 medium with 10% volume fraction of inactivated fetal bovine serum (penicillin 100U / ml, streptomycin 100mg / L), at 37°C, 5% CO 2 , cultured under saturated humidity conditions. Cells in the logarithmic growth phase were collected, stained with 0.4% trypan blue, and the cell viability was detected to be higher than 95%, adjusted to a concentration of 1.0×10 7 ml of cell suspension. Under sterile conditions, the cell suspension was inoculated subcutaneously in the right axilla of nude mice at 0.2 ml / only, and continued to be fed for 2 weeks to establish a tumor-bearing nude mouse model.

[0027] The animals were fed with drinking water and oral medicines respectively. 15 animals in each group were administered once a day for 7 consecutive days. After the last administration, the animals were killed by dislocation of the cervical spine, the tumor tissue was dissected, and the tumor mass was weighed with an electron...

Embodiment 5

[0031] Human gastric cancer cells SGC-7901 were cultured in RPMI1640 culture medium with 10% inactivated fetal bovine serum (penicillin 100U / ml, streptomycin 100mg / L) at 37°C, 5% CO 2 , cultured under saturated humidity conditions. Cells in the logarithmic growth phase were collected, stained with 0.4% trypan blue, and the cell viability was detected to be higher than 95%, adjusted to a concentration of 1.0×10 7 ml of cell suspension. Under sterile conditions, the cell suspension was inoculated subcutaneously in the right axilla of nude mice at 0.2 ml / only, and continued to be fed for 2 weeks to establish a tumor-bearing nude mouse model.

[0032] The animals were fed with drinking water and oral medicines respectively. 15 animals in each group were administered once a day for 7 consecutive days. After the last administration, the animals were killed by dislocation of the cervical spine, the tumor tissue was dissected, and the tumor mass was weighed with an electronic balanc...

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PUM

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Abstract

The invention relates to an antitumor pharmaceutical composition, particularly relates to a pharmaceutical composition used for treating stomach cancer, and specifically relates to an antitumor pharmaceutical composition containing capecitabine, oleuropein and glycyrrhizin. The molar ratio of the capecitabine to the oleuropein to the glycyrrhizin is sequentially as follows: (8-25): (5-10): (3-8). The three compounds, namely capecitabine, oleuropein and glycyrrhizin in the pharmaceutical composition provided by the invention can mutually generate an obvious synergistic effect, to achieve a better curative effect, so as to reduce the treatment dosage of the capecitabine and reduce the side effects of the capecitabine.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical composition containing capecitabine for treating gastric cancer. Background technique [0002] Gastric cancer is a common malignant disease, one of the main causes of death worldwide, and brings great difficulties to clinical treatment. Due to the hidden onset of gastric cancer, most of the clinically diagnosed gastric cancer patients in China currently have It is an advanced stage, and less than 50% of gastric cancer patients are detected early. The medical effect of advanced gastric cancer is not satisfactory. According to domestic data, the 5-year survival rate of advanced gastric cancer is only about 15%, and foreign data is only 5-40%. At present, the methods that are often used in the treatment of gastric cancer are as follows: [0003] Radical surgery: At present, the effective treatment of gastric cancer is still based on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7068A61P35/00A61K31/7048A61K31/352
Inventor 宋婷婷王寿世杨诚
Owner 宋婷婷
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