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Traditional Chinese medicinal composition for treating hypothyroidism and application thereof

A technology for thyroid function and composition, which is used in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas to achieve the effects of less medicinal taste, definite clinical efficacy, and easy quality control

Active Publication Date: 2014-06-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Subclinical hypothyroidism has adverse effects on in vitro fertilization-embryo transfer. Regulating thyroid autoimmune function before and during treatment in in vitro fertilization-embryo transfer has important clinical value, but there is no effective intervention at present

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Granule preparation of the present invention

[0013] The composition of the pharmaceutical composition: 100g of Jasmine japonicus, 200g of capillary, 150g of rehmannia, 200g of rehmannia, 150g of Atractylodes macrocephala, 100g of mulberry leaves, and 100g of light bamboo leaves.

[0014] Preparation:

[0015] (1) Add 10 times the volume of 70% ethanol to reflux extraction for 1.0 hour for the above seven herbs, jiaoshanzhi, yinchen, rehmannia glutinosa, rehmannia glutinosa, Atractylodes macrocephala, mulberry leaves, and light bamboo leaves. Extract twice in total, combine the extracts, and recover ethanol. Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative densi...

Embodiment 2

[0017] Example 2 Tablet preparation of the present invention

[0018] The composition of the pharmaceutical composition: 100g of Jasmine japonicus, 200g of capillary, 150g of rehmannia, 200g of rehmannia, 150g of Atractylodes macrocephala, 100g of mulberry leaves, and 100g of light bamboo leaves.

[0019] Preparation:

[0020] (1) Add 10 times the volume of 70% ethanol to reflux extraction for 1.0 hour for the above seven herbs, jiaoshanzhi, yinchen, rehmannia glutinosa, rehmannia glutinosa, Atractylodes macrocephala, mulberry leaves, and light bamboo leaves. Extract twice in total, combine the extracts, and recover ethanol. Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density of...

Embodiment 3

[0022] Example 3 Capsule preparation of the present invention

[0023] The composition of the pharmaceutical composition: 100g of Jasmine japonicus, 200g of capillary, 150g of rehmannia, 200g of rehmannia, 150g of Atractylodes macrocephala, 100g of mulberry leaves, and 100g of light bamboo leaves.

[0024] Preparation:

[0025] (1) Add 10 times the volume of 70% ethanol to reflux extraction for 1.0 hour for the above seven herbs, jiaoshanzhi, yinchen, rehmannia glutinosa, rehmannia glutinosa, Atractylodes macrocephala, mulberry leaves, and light bamboo leaves. Extract twice in total, combine the extracts, and recover ethanol. Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density ...

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PUM

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Abstract

The invention provides a traditional Chinese medicinal composition for treating hypothyroidism. The traditional Chinese medicinal composition is prepared from the following raw medicinal materials in parts by weight: 100-300 parts of stir-baked fructus gardeniae, 200-500 parts of oriental wormwood, 150-450 parts of prepared rehmannia root, 200-500 parts of raw rehmannia root, 150-450 parts of bighead atractylodes rhizome, 100-300 parts of mulberry leaf and 100-300 parts of lophatherum gracile. The traditional Chinese medicinal composition is supported by the solid classic theory of gynecology of traditional Chinese medicine, is reasonable in component composition and exact in curative effect, can be used for remarkably increasing the clinical pregnancy rate, does not have toxic or side effect, is safe to take and easy to control quality due to few medicinal materials at low cost, and can be applied to preparation of the traditional Chinese medicinal composition for treating sub-clinical hypothyroidism in in-vitro fertilization-embryo transplantation.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine composition, and relates to a traditional Chinese medicine composition for treating subclinical hypothyroidism in in vitro fertilization-embryo transfer, which can be used in the preparation of medicines for treating subclinical hypothyroidism in in vitro fertilization-embryo transfer . Background technique [0002] Subclinical hypothyroidism, referred to as subclinical hypothyroidism (SCH), is based on elevated serum thyroid-stimulating hormone (TSH) levels, while free triiodothyronine (FT3) and free thyroxine (FT4) are within the normal range These patients may have no obvious clinical symptoms and are mainly diagnosed by laboratory tests. The incidence of subclinical hypothyroidism in women of childbearing age is 0.5% to 5%, and the incidence in infertile women is higher, about 4% to 8.5%. The thyroid gland is an important endocrine organ that regulates the body's metabolism. The thyroxine se...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P5/14
Inventor 曲凡周珏胡燕军杨东霞顾颖尔
Owner ZHEJIANG UNIV
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