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Pharmaceutical composition containing small-molecular active peptides

A small-molecule active peptide and composition technology, which is applied in the direction of drug combinations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as no reports on the application of small-molecule active peptides, and achieve the reduction of eosinophils. The number of cells, strong antibacterial effect, and the effect of improving immunity

Inactive Publication Date: 2014-06-25
陈光健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no reports on the application of small molecule active peptides in rhinitis

Method used

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  • Pharmaceutical composition containing small-molecular active peptides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] According to the volume ratio of the rhinitis water product, add 0.45% chlorhexidine gluconate, 15% glycerin and 1.0% hydrogenated castor oil to 3.0% small molecule active peptide (sequence HE), stir and heat to dissolve, mix After uniformity, stop heating and add 800ml of purified water. When the temperature drops to 25°C, add 0.01% mint essence and 0.05% fragrant rice essence, stir and mix well, pass through a 0.45μm microporous membrane, and purify After the water is replenished to 1000ml, it is filled, 15ml per bottle, sealed by electromagnetic induction, and sterilized by damp heat at 95°C for 30 minutes.

Embodiment 2

[0031] Add 0.3% chlorhexidine gluconate, 15% glycerin and 0.6% hydrogenated castor oil to 3.0% small molecule active peptide his-tyr-tyr, stir and heat to dissolve, mix well, stop heating and add 1000ml Purified water, when the temperature drops to 40°C, add 0.01% mint essence and 0.03% fragrant rice essence, stir and mix well, pass through a 0.45μm microporous membrane, add purified water to the filtrate to make up to 2000ml, and then fill it. 15ml per bottle, sealed by electromagnetic induction, and sterilized by moist heat at 95°C for 30 minutes.

Embodiment 3

[0033] Add 0.5% chlorhexidine gluconate, 18% glycerin and 1.0% hydrogenated castor oil to 5.0% small molecule active peptide glu-glu-glu-glu, stir and heat to dissolve, mix well, stop heating Add 3000ml of purified water, and when the temperature drops to 20°C, add 0.013% mint essence and 0.05% fragrant rice essence, stir and mix well, pass through a 0.45μm microporous filter membrane, add purified water to the filtrate to 4000ml, and then fill , 15ml per bottle, sealed by electromagnetic induction, and then sterilized by moist heat at 95°C for 30 minutes.

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PUM

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Abstract

The invention discloses a pharmaceutical composition containing small-molecular active peptides. The pharmaceutical composition comprises the following constituents: small-molecular active peptides, chlorhexidine gluconate, glycerol, hydrogenated castor oil, peppermint essence and rice essence. As a spray, the pharmaceutical composition has relatively strong antibacterial action, can inhibit staphylococcus aureus, candida albicans, Escherichia coli and other bacteria, and is applicable to cleaning and disinfection of nasal cavities. The pharmaceutical composition has an obvious effect on crowds with nasal obstruction, rhinorrhea with turbid discharge, sneezing, headache, hyposmia, mycteroxerosis and the like caused by acute and chronic rhinitis, allergic rhinitis, nasosinusitis, influenza and the like, and has no toxic or side effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing small molecular active peptides. Background technique [0002] Rhinitis is an inflammation of the nasal mucosa caused by bacteria, viruses, allergens, various physical and chemical factors, and certain systemic diseases. increase. Today, as the air quality is getting worse and worse, the incidence of rhinitis is also increasing. Various viruses and bacteria are breathed into our nasal cavity along with the dust in the air, and adhere to the nasal mucosa, causing symptoms such as inflammation and edema of the nasal mucosa. Therefore, it is necessary to find a formula that can clean the nasal cavity, prevent and treat rhinitis Drugs are the most urgent problem at present. [0003] Studies have found that small molecular active peptides composed of 2-4 amino acids can not only directly enter cells through the cell membrane to improve cell rep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/07A61K38/06A61K38/05A61P11/02A61P11/00A61P31/02A61K31/155
CPCY02A50/30
Inventor 陈光健
Owner 陈光健
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