An ultrasonic dissolution accelerator and its method and application for accelerating drug dissolution
A technology of ultrasonic dissolution and accelerator, applied in the direction of chemical instruments and methods, dissolution, dissolution, etc., to achieve uniform dissolution, good dissolution promoting effect, and low power consumption
Inactive Publication Date: 2016-03-30
XI AN JIAOTONG UNIV
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Problems solved by technology
[0004] At present, the application of ultrasound in dissolution is mainly in the extraction of traditional Chinese medicine inspection, and there is almost no application in the dissolution of injection medicine. However, the disadvantages of traditional injection medicine dissolution methods are becoming more and more prominent. Therefore, it is urgent to study a universal injection medicine instant dissolving device and method
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[0036] An ultrasonic dissolution accelerator scheme to accelerate the dissolution of injection drugs: use ultrasonic transducers to generate high-power ultrasound to act on drugs, mainly through the mechanical action of ultrasound on drugs to accelerate the dissolution process of drugs. Using a single-chip microcomputer to control the work of the ultrasonic transducer, adjust its power, frequency, intensity and action time and other parameters, and emit ultrasonic waves to act on the drug to promote its uniform dissolution in the solvent.
[0037] One of the cores of this scheme is to use the power amplifier circuit to drive the ultrasonic transducer to generate ultrasonic waves. The frequency drift of the ultrasonic transducer will occur during the working process. Only when it works near its center frequency can its output power be sufficient to have an effect on drug dissolution. In order to determine the frequency of the ultrasonic transducer, a feedback signal is extracte...
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The invention provides an ultrasonic dissolution accelerator as well as a method and application of the ultrasonic dissolution accelerator for accelerating drug dissolution. The ultrasonic dissolution accelerator comprises a container and an ultrasonic generation device connected with the container. A position between an ultrasonic transducer of the ultrasonic generation device and the container is filled with water as a coupling medium, a utensil with a solvent and drugs to be dissolved is put into the container, and ultrasonic waves generated by the ultrasonic transducer penetrate through the utensil to act on the drugs to be dissolved, so that the drugs to be dissolved are dissolved in the solvent in an accelerated manner. Compared with existing drug dissolution acceleration means, the novel ultrasonic dissolution accelerator for accelerating the drug dissolution has the advantages that a relatively good dissolution acceleration effect can be achieved with the relatively low power consumption within the relatively short time; a frequency synthesizer, a power amplifier, the ultrasonic transducer, a singlechip and a feedback circuit are adopted to form a closed-loop control system, so that the ultrasonic transducer can stably work and the dissolution acceleration process can be conveniently controlled by adjusting parameters.
Description
technical field [0001] The invention relates to the field of promoting drug dissolution by utilizing the mechanical effect of power ultrasound, in particular to an ultrasonic dissolution accelerator and a method and application for accelerating drug dissolution. Background technique [0002] Medical injection drugs must be dissolved in normal saline or glucose solution before injection, in order to be fully absorbed by the human body and achieve the expected drug effect. Because of the dissolution rate problem, some drugs have brought a lot of workload to doctors and nurses in practical application. The existing methods of drug dissolution include stirring, magnetic stirring, hand shaking, dipping, boiling, water bath and the like. Using the hand shaking method, water bath method, etc. requires a lot of work, and the shaking and other processing processes are likely to cause liquid leakage or incomplete dissolution, which is time-consuming, labor-intensive and consumable. ...
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IPC IPC(8): B01F11/02B01F1/00
Inventor 周秦武白平宋亚楠陈星吴德东张大龙
Owner XI AN JIAOTONG UNIV