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Cefpodoxime proxetil pellets and capsules and preparation method thereof

A technology for cefpodoxime axetil and cefpodoxime, which is applied in the field of pharmaceutical preparations, can solve the problems of being difficult to satisfy cefpodoxime axetil taste and stable quality, unfavorable to industrialized production, complicated preparation process, etc., and achieves improved compliance and cost. Low, good taste effect

Inactive Publication Date: 2014-07-16
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method uses many auxiliary materials, and the preparation process is complicated, and the equipment used is many, which is unfavorable for industrialized production
[0006] In view of the above deficiencies and the preparation of existing methods, it is difficult to satisfy the mouthfeel and stable quality of cefpodoxime axetil, and there are great difficulties in long-term preservation, so a method that can solve these problems is urgently needed

Method used

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  • Cefpodoxime proxetil pellets and capsules and preparation method thereof
  • Cefpodoxime proxetil pellets and capsules and preparation method thereof
  • Cefpodoxime proxetil pellets and capsules and preparation method thereof

Examples

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Embodiment 1

[0044] This example is the preferred prescription of the cefpodoxime axetil pellets provided by the present invention, including two parts, the base pill prescription and the protective layer prescription, which are described in detail as follows.

[0045] Cefpodoxime axetil pellets include a base pellet and a protective layer, and the composition is as follows:

[0046] a. Base pill:

[0047]Cefpodoxime Proxetil 60g 60%

[0048] Hydroxypropyl Methyl Cellulose 18g 18%

[0049] Mannitol 8g 8%

[0050] b. Protective coating (i.e. the protective layer):

[0051] Hydroxypropyl Methyl Cellulose 7g 7%

[0052] Diacetylglycerides 3g 3%

[0053] Talc 2g 2%

[0054] Below is the preparation method of the cefpodoxime axetil pellet of the present embodiment, comprises the following steps:

[0055] 1) Preparation of base pellets:

[0056] Dissolve 18g of hydroxypropylmethylcellulose in an appropriate amount of purified water to form a 5% aqueous solution of hydroxypropylmethylcell...

Embodiment 2

[0061] Cefpodoxime axetil pellets comprise base pill and protective layer, preferably following composition:

[0062] a. Base pill:

[0063] Cefpodoxime Proxetil 60g 60%

[0064] Hydroxypropyl Methyl Cellulose 15g 15%

[0065] Mannitol 6g 6%

[0066] b. Protective coating:

[0067] Hydroxypropyl Methyl Cellulose 5g 5%

[0068] Diacetylglycerides 4g 4%

[0069] Talc 2.5g 2.5%

[0070] The present embodiment is the preparation method of cefpodoxime axetil pellet provided by the present invention, comprises the following steps:

[0071] 1) Preparation of base pellets:

[0072] Dissolve 15g of hydroxypropylmethylcellulose in an appropriate amount of purified water to form a 7% aqueous solution of hydroxypropylmethylcellulose, weigh 60g of 80-mesh cefpodoxime axetil, and mix with 5g of mannitol to obtain a mixed powder , take the mixed powder accounting for 15% of the total weight of the mixed powder, place it in the coating pan of the coating granulator (model: BY-600), ad...

Embodiment 3

[0077] Cefpodoxime axetil pellets comprise base pill and protective layer, preferably following composition:

[0078] a. Base pill:

[0079] Cefpodoxime Proxetil 60g 60%

[0080] Hydroxypropyl Methyl Cellulose 12g 12%

[0081] Mannitol 10g 10%

[0082] b. Protective coating:

[0083] Hydroxypropyl Methyl Cellulose 8g 8%

[0084] Diacetylglycerides 3g 3%

[0085] Talc 2g 2%

[0086] The present embodiment is the preparation method of cefpodoxime axetil pellet provided by the present invention, comprises the following steps:

[0087] 1) Preparation of base pellets:

[0088] Dissolve 12g of hydroxypropylmethylcellulose in an appropriate amount of purified water to form a 6% aqueous solution of hydroxypropylmethylcellulose, weigh 60g of 80-mesh cefpodoxime axetil, and mix with 10g of mannitol to obtain a mixed powder , take the mixed powder accounting for 15% of the total weight of the mixed powder, place it in the coating pan of the coating granulator (model: BY-600), adj...

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Abstract

The invention discloses cefpodoxime proxetil pellets and capsules and a preparation method thereof. The pellets are composed of the following raw materials: 55 to 70 percent of cefpodoxime proxetil, 10.5 to 30 percent of hydroxypropyl methyl cellulose, 6 to 12 percent of mannitol, 1 to 5 percent of diacetyl glycerin monoester, and 1 to 3 percent of talcum powder. The method is low in cost, simple in process, and applicable for industrial production. The prepared capsules are good in quality, and are free of gravel taste after taking. The cefpodoxime proxetil has good taste, flowability, and content uniformity so as to be well preserved for a long time.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefpodoxime axetil pellet, a capsule and a preparation method thereof. Background technique [0002] Cefpodoxime axetil is the third-generation oral broad-spectrum cephalosporin, which is hydrolyzed into cefpodoxime on the intestinal wall after oral administration and absorbed by the intestinal tract. Cefpodoxime has a broad-spectrum and powerful antibacterial effect and a long half-life, and is widely used in the treatment of respiratory tract, urinary tract, obstetrics and gynecology infectious diseases and suppurative otitis media. [0003] Cefpodoxime Proxetil (CPDX-PR) was first listed in Japan in 1990. Its structure is characterized by a methoxyiminothiazolyl group at the 7th position of the cephalosporin skeleton, a methoxymethyl group at the 3rd position, and a carboxylic acid at the 4th position. There is Proxetil base. CPDX-PR is the prodrug of cefpodoxime...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/48A61K31/546A61K47/38A61K47/26A61K47/14A61K47/02A61P31/04
Inventor 刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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