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Lycopene-SOD (Superoxide Dismutase) enteric capsule and preparation method thereof

A technology of lycopene and enteric-coated capsules, applied in the field of medicine, can solve problems such as unstable properties

Inactive Publication Date: 2014-07-16
LANZHOU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Both lycopene and SOD are easily oxidizable substances with unstable properties, which is a technical problem faced by existing related products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0042] 1. Preparation of lycopene-β-cyclodextrin inclusion complex enteric-coated granules

[0043] 1. Take 1440g of β-cyclodextrin, add 4 times the amount of 20% edible ethanol, add in 4 times, add 1440ml each time, and grind it into a uniform paste with a colloid mill.

[0044] 2. Take another 1440g of lycopene oleoresin, add 1440ml (1 times the amount) of 95% edible ethanol, and grind it into a uniform paste with a colloid mill.

[0045] 3. Slowly add lycopene paste to the β-cyclodextrin paste under the state of colloid mill grinding, and continue grinding for 30 minutes.

[0046] 4. Under the grinding state of the colloid mill, slowly add 463.2g of micro-powdered silica gel, and continue to grind evenly.

[0047] 5. Put the ground paste in an enamel tray, the thickness of the paste is not more than 6mm, dry it with cold air, grind it, and pass through a 100-mesh sieve to obtain a powder.

[0048] 6. Take 16.8g of gum arabic, add distilled water to 1680mL (100 times the a...

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PUM

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Abstract

The invention discloses a lycopene-SOD (Superoxide Dismutase) enteric capsule and a preparation method thereof. The preparation method is characterized by comprising the following steps: grinding 5wt% of lycopene oil resin into lycopene beta-CD molecular inclusion complex in the presence of beta-CD which is 20 times as much as lycopene oil resin; then preparing lycopene beta-CD molecular inclusion complex into 40-mesh granules; coating the lycopene beta-CD molecular inclusion complex granules with enteric-soluble coated premix auxiliary materials to obtain enteric coated granules. According to the preparation method, easily-oxidized groups in lycopene are embedded in a molecule well of beta-CD for protection so that the stability of products in shelf life is improved; and since the enteric-soluble material is used for coating for further protection so as to prevent lycopene from being damaged in gastric acid and control the release of granules in an enteric canal so as to improve the bioavailability. In order to further improve the stability of SOD and directly conveying the SOD to small intestinal to be absorbed for improving the bioavailability, the molecule embedding is carried out on SOD by beta-cyclodextrin which is at least 50 times as much as SOD according to a grinding method, and then the bedded SOD is prepare into 40-mesh granules, and finally the granules are coated with the enteric-soluble coated premix auxiliary materials to obtain the enteric-soluble granules, so that the stability of the product in the shelf life can be improved, and the damage of the product in the gastric acid can be avoided.

Description

technical field [0001] The invention relates to a capsule and a preparation method thereof, in particular to a lycopene-SOD enteric-coated capsule and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Both lycopene and SOD are easily oxidizable substances with unstable properties, which is a technical problem faced by existing related products. Therefore, it is necessary to adopt corresponding technical means to further improve its stability. Contents of the invention [0003] The first object of the present invention is to greatly improve the stability of lycopene and LA-SOD by embedding β-cyclodextrin molecules respectively on lycopene oleoresin and LA-SOD, granulating, and wrapping with enteric coating sex. [0004] The second purpose of the present invention is to prepare the health food "lycopene-SOD enteric-coated capsule" with content and stability meeting the requirements through certain technology. [0005...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/48A23L1/29A61K38/44A61P39/06A61P37/02A61K31/01A23L33/00
Inventor 尹得仲刘晓风杨林
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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