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Composition and application thereof for preparing cellulose hard capsules

A technology of hard capsules and cellulose, which is applied in the fields of capsule delivery, medical preparations with inactive ingredients, food science, etc. To achieve the effect of reduced viscosity, easy molding, and shortened paste wire

Inactive Publication Date: 2016-08-17
吉林金天大健康集团胶囊有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the price of hydroxypropyl methylcellulose is not very expensive, the glue water material is relatively large in the production process, and it is difficult to remove water. The disintegration time limit of capsules prepared with it as the main raw material is relatively long. Therefore, currently The domestic market share is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 12wt% hydroxypropyl methylcellulose (at 20°C, the aqueous solution of 2wt% hydroxypropylmethylcellulose has a viscosity of 7.0mpa s), 7wt% soluble tapioca starch (at 20°C When the concentration is 9wt%, the aqueous solution of soluble tapioca starch has a viscosity of 5.0mpa s, and the soluble tapioca starch of this viscosity is obtained by hydrochloric acid treatment of tapioca starch), 0.4wt% carrageenan and the rest of the water are mixed to obtain Composition for the preparation of cellulose hard capsules.

[0018] A conventional capsule preparation process is adopted to prepare a cellulose hard capsule by using the above-mentioned composition for preparing a cellulose hard capsule. The prepared cellulose hard capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition, and the disintegration experiment was carried out by using Tianda Tianfa ZB-1E intelligent disintegration instrument, and all 50 s...

Embodiment 2

[0020] Mix 22wt% hydroxypropyl methylcellulose (at 20°C, the aqueous solution of 2wt% hydroxypropylmethylcellulose has a viscosity of 3.0mpa s), 3wt% soluble potato starch (at 20°C When the concentration is 9wt%, the aqueous solution of soluble potato starch has a viscosity of 20.0mpa s, and the soluble potato starch of this viscosity is obtained by treating potato starch with sulfuric acid), 2wt% locust bean gum and the rest of the water are mixed to obtain Composition for the preparation of cellulose hard capsules.

[0021] A conventional capsule preparation process is adopted to prepare a cellulose hard capsule by using the above-mentioned composition for preparing a cellulose hard capsule. The prepared cellulose hard capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. Tianda Tianfa ZB-1E intelligent disintegration instrument was used for disintegration experiments. All 50 samples were tested and ...

Embodiment 3

[0023] 25wt% hydroxypropyl methylcellulose (at 20°C, the aqueous solution of 2wt% hydroxypropylmethylcellulose has a viscosity of 3.0mpa s), 0.5wt% soluble corn starch (at 20 At ℃, the aqueous solution of 9wt% soluble cornstarch has a viscosity of 300.0mpa·s, and the soluble cornstarch of this viscosity is obtained by treating cornstarch with hydrochloric acid), 1wt% of gum arabic and the rest of the water are mixed to obtain Composition for the preparation of cellulose hard capsules.

[0024] A conventional capsule preparation process is adopted to prepare a cellulose hard capsule by using the above-mentioned composition for preparing a cellulose hard capsule. The prepared cellulose hard capsules were disintegrated with reference to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition, and the disintegration experiment was carried out by using Tianda Tianfa ZB-1E intelligent disintegration instrument, and all 50 samples could be disintegrated wit...

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Abstract

The invention relates to a composition used for preparing a cellulose hard capsule and application thereof. The composition consist of 12wt%-25wt% of hydroxypropyl methyl cellulose, 0.5wt%-7wt% of soluble starch, 0.4wt%-2wt% of gelling agent and the balance of water, wherein aqueous liquor of the hydroxypropyl methyl cellulose with concentration of 2wt% at 20 DEG C has viscosity of 3 mpa.s-7mpa.s; and aqueous liquor of the soluble starch with concentration of 9wt% at 20 DEG C is 5mpa.s-300mpa.s. According to the composition, since a proper amount of soluble starch is added into cellulose substrate to improve the cellulose substrate, viscosity of mixed components is lowered, paste fibers get short and easy to form, so that production efficiency is improved; meanwhile, a compact structure of the cellulose hard capsule in a dissolving process is effectively broken, dissolution speed of the hydroxypropyl methyl cellulose substrate is accelerated, disintegration is effectively promoted, and drug release is quickened.

Description

technical field [0001] The present invention relates to a composition for preparing hard cellulose capsules for food, medicine, etc., and the application of the composition. Background technique [0002] Capsules made from animal-derived gelatin have been around for at least 200 years. Since gelatin can mask the bad taste, smell or irritation to the stomach of many medicines, gelatin capsules are quickly promoted and used in the production of various solid preparations. Over the past 100 years, various capsules made of gelatin have been sold well in the international pharmaceutical market for a long time. At the end of the last century, the outbreak of mad cow disease finally dragged gelatin capsules into an unprecedented crisis of confidence. In April 2012, the "poisonous capsule" incident that broke out in my country undoubtedly aggravated the distrust of the Chinese people towards gelatin capsules. In addition, gelatin capsules themselves have many disadvantages, such ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/36A23L33/00
Inventor 王文辉闫丰文袁国卿
Owner 吉林金天大健康集团胶囊有限公司