The preparation method of rifapentine
A technology of rifapentine and rifaxazine, which is applied in the field of preparation of rifapentine, can solve the problems of increasing impurities and reducing yield, and achieves the effect of high impurity content, good stability and uniform particles
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[0019] The present invention will be further described in detail through specific implementation examples below.
[0020] The embodiment of the present invention provides a preparation method of rifapentine, comprising the following steps:
[0021] A. Taking rifamycin S as the starting material, reacting with dimethylol terbumine in the first organic solvent and converting it into intermediate rifaxazine;
[0022] B. In the second organic solvent, adding a catalyst and a reducing agent to hydrolyze and open the intermediate rifaxazine;
[0023] C. The hydrolyzate of rifaoxazine is condensed into rifapentine solution with 1-amino-4-cyclopentylpiperazine;
[0024] D. Filtration of the rifapentine solution, segmental crystallization of multi-stage crystallization temperature, first separation, washing, second separation, drying, soaking, third separation, rinsing, spin-drying, sieving, drying , Mixing and refining process to get Rifapentine finished product.
[0025] Using rif...
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