Electrochemical glucose sensor based on modification of graphene and nano-particle and application thereof

Abstract

The invention discloses an electrochemical glucose sensor based on modification of graphene and nano-particle and application thereof. The electrochemical glucose sensor is composed of a reference electrode, an auxiliary electrode and a work electrode, wherein the work electrode comprises a chromium layer, an inert electrode layer, a graphene layer, a metal nano-particle layer and a glucose oxidase layer which are arranged in sequence; the reference electrode, the auxiliary electrode and the work electrode are adhered on a glass substrate respectively through the chromium layer. The application of the electrochemical glucose sensor is as follows: the electrochemical glucose sensor based on modification of the graphene and nano-particle and a microfluidic chip for tissue fluid transdermal extraction are integrated; the glass substrate in the electrochemical glucose sensor and a bonding surface of the microfluidic chip are bonded together; electrode ends of the reference electrode, the auxiliary electrode and the work electrode in the electrochemical glucose sensor are arranged in a microfluidic channel of the microfluidic chip. The electrochemical glucose sensor is high in measurement precision and small in volume and achieves integration of continuous measurement of glucose concentration in the tissue fluid and tissue fluid transdermal extraction.

Description

technical field [0001] The invention relates to a sensor for continuous detection of glucose concentration in human tissue fluid. In particular, it relates to an electrochemical glucose sensor based on graphene and nanoparticle modification that can be integrated with a microfluidic chip for transdermal extraction of interstitial fluid and its application. Background technique [0002] With the improvement of people's living standards, changes in diet structure and lifestyle, population aging and the increase in the incidence of obesity, the incidence of diabetes is increasing year by year. The importance of continuous blood glucose monitoring in the diagnosis and treatment of diabetes has been increasingly recognized by people. If painless and uninterrupted continuous blood glucose monitoring can be performed on patients and more closely data on continuous changes in blood glucose concentration can be provided, it will be able to reflect the "full picture" of the patient's...

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Problems solved by technology

However, the instantaneous blood sugar concentration is easily affected by many factors such as exercise, diet, drugs, mood swings, etc., and there is a certain one-sidedness and inaccuracy

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