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Production method of cepharanthin

A production method, the technology of stephatrin, applied in the direction of organic chemistry, etc., can solve the problems of waste, rough process, and low collection ratio of stephatrin, and achieve the effect of high collection rate and improved collection rate

Inactive Publication Date: 2014-09-10
施佩蓓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the rough process, the current method of making stephin, the collection ratio of stephin is low, resulting in a large amount of waste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The present invention provides a kind of production method of patinol, it is characterized in that, comprises the steps:

[0015] S1. Take 1 kg of ground root powder, add 0.6L of 5% sodium carbonate, and let it stand for 2 hours, so that the plant tissue can fully absorb the lye;

[0016] S2, add 1.5L benzene to soak for 70 hours, filter, then add 1.5L benzene to soak for 46 hours;

[0017] S3. Collect the benzene liquid, combine the benzene liquid twice, add 10% hydrochloric acid to extract, during the acid extraction process, a large amount of white porridge precipitates, which is easy to emulsify, and the benzene liquid is extracted with acid until it does not contain alkaloids. Alkaline with saturated sodium carbonate solution, add sodium carbonate solution for alkalization, add chloroform to the alkalization solution and extract 4 times.

[0018] S4, adding anhydrous sodium sulfate for drying, recovering chloroform, and obtaining 18 g of total alkaloids in light y...

Embodiment 2

[0024] A kind of production method of stephaniacine, is characterized in that, comprises the steps:

[0025] S1. Take 1 kg of ground root powder, add 0.6L of 5% sodium carbonate, and let it stand for 2.5 hours, so that the plant tissue can fully absorb the lye;

[0026] S2, add 1.5L benzene to soak for 71 hours, filter, then add 1.5L benzene to soak for 47 hours;

[0027] S3. Collect the benzene liquid, combine the benzene liquid twice, add 10% hydrochloric acid to extract, during the acid extraction process, a large amount of white porridge precipitates, which is easy to emulsify, and the benzene liquid is extracted with acid until it does not contain alkaloids. Alkaline with saturated sodium carbonate solution, add sodium carbonate solution for alkalization, add chloroform to the alkalization solution and extract 4 times.

[0028] S4, adding anhydrous sodium sulfate for drying, recovering chloroform, and obtaining 17.3 g of total alkaloids in the form of light yellow film; ...

Embodiment 3

[0034] The present invention provides a kind of production method of patinol, it is characterized in that, comprises the steps:

[0035] S1. Take 1 kg of ground root powder, add 0.6L of 5% sodium carbonate, and let it stand for 3 hours, so that the plant tissue can fully absorb the lye;

[0036] S2, add 1.5L benzene to soak for 72 hours, filter, then add 1.5L benzene to soak for 48 hours;

[0037] S3. Collect the benzene liquid, combine the benzene liquid twice, add 10% hydrochloric acid for extraction, during the acid extraction process, a large amount of white porridge precipitates, which is easy to emulsify, and the benzene liquid is extracted with acid until it does not contain alkaloids. Alkaline with saturated sodium carbonate solution, add sodium carbonate solution for alkalization, add chloroform to the alkalization solution and extract 4 times.

[0038] S4, adding anhydrous sodium sulfate for drying, recovering chloroform, and obtaining 17.5 g of total alkaloids in t...

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PUM

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Abstract

The invention provides a production method of cepharanthin, which comprises the following steps: S1, taking 1kg by weight of stephania epigaea root powder, adding 0.6L 5% sodium carbonate for holding time of 2-3h; S2, adding 1.5L of benzene and soaking for 70-72 hours, filtering, then adding 1.5 L of benzene and soaking for 46-48 hours; S3, collecting benzene solution, adding 10% hydrochloric acid for extraction, adding sodium carbonate solution for alkalinization, and adding chloroform into the alkalinized solution for extraction; S4, adding anhydrous sodium sulfate and drying, recovering chloroform to obtain alkaloid; S5, adding 35ml of acetone for holding time of 2 hours, and adding 10ml of acetone and cleaning; S6, adding 2.5mL of benzene into acetone solution, standing for 10-12 hours, and adding 10mL of acetone and cleaning; and S7, adding chloroform, and eluting and concentrating through an aluminum chloride chromatographic column, to obtain cepharanthin. The recovery rate of the cepharanthin is high and is improved by improvement of the technology, and the technological parameters can be optimized.

Description

technical field [0001] The present invention relates to the production method of stephatrin, in particular to a production method of stephatrin by using ground root powder. Background technique [0002] Cepharanthine, a white blood cell proliferation drug, can promote bone marrow tissue proliferation, thereby increasing white blood cells. For leukopenia. It can increase the peripheral blood leukocytes. Animal experiments have found that it can obviously prevent the leukopenia caused by mitomycin, but it does not inhibit the anticancer effect of mitomycin. Its mechanism of action is to promote the proliferation of bone marrow tissue, thereby producing the effect of increasing white blood cells. It is used for agranulocytosis caused by tumor chemotherapy and radiotherapy and leukopenia caused by other reasons. Due to the roughness of the process, the current method for producing stephin has a low collection ratio of stephin, resulting in a large amount of waste. Contents ...

Claims

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Application Information

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IPC IPC(8): C07D491/22
CPCC07D491/22
Inventor 施佩蓓
Owner 施佩蓓
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