Production method of glycyrrhizin

A production method and technology for glycyrrhizin, which are applied in the field of glycyrrhizin production, can solve the problems of high heavy metal content, rough process, high arsenic content and the like

Inactive Publication Date: 2014-09-10
毛林涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the rough process, the current preparation metho...

Method used

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Examples

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Effect test

Embodiment 1

[0013] The invention provides a kind of production method of glycyrrhizin, comprising the following steps:

[0014] S1. Glycyrrhiza licorice is crushed, soaked in water at 30°C for 6 hours, the extract is concentrated to a paste, dried and crushed to make acid powder;

[0015] S2, leaching the acid powder with ethanol, ammonizing the leachate with ammonia water or ammonia gas until a yellow precipitate—triammonium glycyrrhizinate is separated, and triammonium glycyrrhizinate is separated;

[0016] S3. Acidify triammonium glycyrrhizinate with glacial acetic acid, heat to reflux for 0.5 hour, and let stand the separated crude product of monoammonium glycyrrhizinate.

[0017] S4. Recrystallize the crude product of monoammonium glycyrrhizinate with ethanol and activated carbon, and leave the filtrate for 0.5 hour to separate and obtain high-purity monoammonium glycyrrhizinate. The prepared high-purity glycyrrhizic acid monoammonium salt has an active ingredient of more than 96.23...

Embodiment 3

[0025] The invention provides a kind of production method of glycyrrhizin, comprising the following steps:

[0026] S1. Glycyrrhiza licorice is crushed, soaked in water at 38°C for 24 hours, the extract is concentrated to a paste, dried and crushed to make acid powder;

[0027] S2, leaching the acid powder with ethanol, ammonizing the leachate with ammonia water or ammonia gas until a yellow precipitate—triammonium glycyrrhizinate is separated, and triammonium glycyrrhizinate is separated;

[0028] S3. Acidifying triammonium glycyrrhizinate with glacial acetic acid, heating to reflux for 1 hour, and standing the separated crude product of monoammonium glycyrrhizinate.

[0029] S4. Recrystallize the crude product of monoammonium glycyrrhizinate with ethanol and activated carbon, and leave the filtrate for 4 hours to separate and obtain high-purity monoammonium glycyrrhizinate. The prepared high-purity glycyrrhizic acid monoammonium salt has an active ingredient of more than 95...

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Abstract

The invention provides a production method of glycyrrhizin, which comprises the following steps: S1. pulverizing licorice, soaking in 30-45 DEG C water for 6-36 hours, taking the leach solution, concentrating to paste, drying, and pulverizing to obtain acid powder; S2. leaching the acid powder with ethanol, aminating the leach solution with ammonia water or ammonia gas to obtain a yellow precipitate-triammonium glycyrrhizinate, and separating out the triammonium glycyrrhizinate; and S3. acidifying the triammonium glycyrrhizinate with glacial acetic acid, heating under reflux for 0.5-2 hours, standing, and separating out the mono-ammonium glycyrrhizinate crude product. The method is performed by using heavy-metal-free raw materials and equipment, and optimizes the technological parameters.

Description

technical field [0001] The invention relates to a preparation method of glycyrrhizin, in particular to a method for producing glycyrrhizin by using a licorice plant. Background technique [0002] Glycyrrhizin has anti-allergic, anti-ulcer, anti-allergic, anti-inflammatory, anti-viral hepatitis and hyperlipidemia, anti-cancer, anti-interferon inducer and enhanced cellular immune function clinically. Due to the rough process, the current preparation method of glycyrrhizin contains more heavy metals and arsenic. Contents of the invention [0003] The purpose of the present invention is to provide a method for producing glycyrrhizin, which can solve one or more problems in the above-mentioned prior art. [0004] According to one aspect of the present invention, a kind of production method of glycyrrhizin is provided, comprising the steps: [0005] S1. Glycyrrhiza licorice is crushed, soaked in water at 30-45°C for 6-36 hours, the extract is concentrated to paste, dried and c...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07H15/256C07H1/08
Inventor 毛林涛
Owner 毛林涛
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