Production technology for synthesizing m-bromoanisole
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A technology of bromoanisole and production process, which is applied in the field of production technology for the synthesis of m-bromoanisole, can solve the problems of complex production process, low purity, irritation, etc., and achieves high purity, easy-to-obtain raw materials, and convenience. effect of operation
Inactive Publication Date: 2014-09-17
ANHUI HUARUN PAINTS
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[0002] M-bromoanisole is a colorless to light yellow oily liquid, soluble in alcohol, ether, benzene and carbon disulfide, insoluble in water, irritating, m-bromoanisole is the main intermediate for the synthesis of anticancer sedative analgesic drug trimidol body, and can be used in other medicines, dyestuffs and organic synthesis. At present, the method for industrial production of m-bromoanisole is still a relatively traditional method. There are problems such as low yield, low purity and serious pollution in this traditional production method. And the production process is relatively complicated, it is difficult to meet the needs of human beings
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Embodiment 1
[0019] A kind of production technology that m-bromoanisole is synthesized, comprises following process step,
[0020] a. Select a 1000L enamel reactor as the reaction vessel.
[0021] b. Weigh 390kg of sodium hydroxide solution and 490kg of m-bromophenol solution and place them in the reaction vessel in step a, start stirring to dissolve the mixture.
[0022] c. Pass steam into the jacket of the mixed material that has been stirred in step b for heating, and control the temperature in the kettle at 55°C.
[0023] d. Continue to stir the mixture in the kettle, and add 350kg of dimethyl sulfate dropwise while stirring, and finish adding the dimethyl sulfate dropwise within 2.5h. After the dropwise addition, continue to react for 2.0h.
[0024] e. Cool the product obtained after the reaction in step d, and then put the cooled product into an oil-water separator and let it stand for 4.0 h to separate the oil layer and the water layer.
[0025] f. The oil layer in step e is taken...
Embodiment 2
[0028] A kind of production technology that m-bromoanisole is synthesized, comprises following process steps,
[0029] a. Select a 1000L reactor as the anti-enamel container.
[0030] b. Weigh 400kg of sodium hydroxide solution and 500kg of m-bromophenol solution and place them in the reaction vessel in step a, start stirring to dissolve the mixture.
[0031] c. Pass steam into the jacket of the mixed material that has been stirred in step b for heating, and control the temperature in the kettle at 60°C.
[0032] d. Continue to stir the mixture in the tank, and add 380kg of dimethyl sulfate dropwise while stirring, and complete the dropwise addition of dimethyl sulfate within 3.0h. After the dropwise addition, continue to react for 2.0h.
[0033] e. Cool the product obtained after the reaction in step d, and then put the cooled product into an oil-water separator and let it stand for 4.0 h to separate the oil layer and the water layer.
[0034] f. The oil layer in step e is ...
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Abstract
A production technology for synthesizing m-bromoanisole relates to the technical filed of the chemical industry. The technology comprises the following steps: weighing a sodium hydroxide solution and an m-bromophenol solution, adding the sodium hydroxide solution and the m-bromophenol solution into a reaction container, stirring a mixture for dissolving, introducing steam for heating, adding dimethyl sulfate in a dropwise manner, adding the obtained cooled product to an oil-water separator, allowing the product to stand for separating in order to obtain an oil layer and a water layer, extracting the water layer by ether, drying the obtained ether layer by anhydrous calcium chloride, adding the dried ether layer to a distillation kettle, distilling, mixing residues obtained after the distillation with the oil layer for later use, adding the obtained residue and oil layer mixture to a rectifying tower, carrying out reduced pressure distillation, and collecting the obtained fraction which is the m-bromoanisole finished product. The technology has the advantages of convenient and simple preparation, environmental protection, no pollution, easily available materials, less equipment investment, high purity and convenient operation, and the prepared m-bromoanisole has the advantages of good use effect, safety and reliability.
Description
technical field [0001] The invention relates to the technical field of chemical engineering, in particular to a production process for the synthesis of m-bromoanisole. Background technique [0002] M-bromoanisole is a colorless to light yellow oily liquid, soluble in alcohol, ether, benzene and carbon disulfide, insoluble in water, irritating, m-bromoanisole is the main intermediate for the synthesis of anticancer sedative analgesic drug trimidol body, and can be used in other medicines, dyestuffs and organic synthesis. At present, the method for industrial production of m-bromoanisole is relatively traditional. There are problems such as low yield, low purity and serious pollution in this traditional production method. Moreover, the production process is relatively complicated, and it is difficult to meet the needs of human beings. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a production process for the syn...
Claims
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