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Allergen obstructing agent for respiratory tract and preparation method thereof

A technology of allergens and blocking agents, applied in the field of medical devices, can solve the problems of complex components, uncomfortable feeling, high price, etc., and achieve the effects of low price, reduced incidence, and prevention of inhalation allergy

Inactive Publication Date: 2014-10-01
方翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Nasal allergen blockers currently on the market have the following characteristics: (1) The composition is complex, such as cyclodextrin, which will leave solid powder in the nasal cavity during application and cause obvious discomfort; and The product contains surfactant polysorbate 80, preservatives methylparaben and propylparaben, antioxidants and other excipients, some of which have sensitizing effects; (2) expensive, imported pollen blockers, Although the curative effect is good, it has the disadvantage of being expensive

Method used

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  • Allergen obstructing agent for respiratory tract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] This embodiment provides a respiratory allergen blocker, comprising the following components by weight: 85% white oil, 5% vaseline, 5% paraffin, and 5% microcrystalline wax, wherein the kinematic viscosity of white oil is 70% at 40°C. ~100m 2 / s.

[0018] The method for making above-mentioned respiratory allergen blocker is:

[0019] Mix the above components together, heat to 65°C, stir at the same time, mix thoroughly and then cool to get the finished product.

Embodiment 2

[0021] This embodiment provides a respiratory allergen blocker, comprising the following components by weight: 70% white oil, 5% vaseline, 15% paraffin, and 10% microcrystalline wax, wherein the kinematic viscosity of white oil is 70% at 40°C. ~100m 2 / s.

[0022] The method for making above-mentioned respiratory allergen blocker is:

[0023] Mix the above components together, heat to 80°C, stir at the same time, mix thoroughly and then cool to get the finished product.

Embodiment 3

[0025] This embodiment provides a respiratory allergen blocker, comprising the following components by weight: 80% white oil, 8% petrolatum, 5% paraffin, and 7% microcrystalline wax, wherein the kinematic viscosity of white oil is 70% at 40°C. ~100m 2 / s.

[0026] The method for making above-mentioned respiratory allergen blocker is:

[0027] Mix the above components together, heat to 100°C, stir at the same time, mix thoroughly and then cool to get the finished product.

[0028] Utilize above-mentioned embodiment 1~3 composition and the airway allergen blocking agent that method makes, carry out following test to guinea pig:

[0029] 40 guinea pigs were randomly divided into:

[0030] Group A: normal saline injection group (control group): 8 rats

[0031] Group B: injection with ragweed extract + ragweed pollen inhalation group: 8 rats

[0032] Group C: injection with ragweed extract + ragweed pollen inhalation + respiratory allergen blocker (using the blocker in Example...

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Abstract

The invention relates to the field of medical instruments, specifically to an allergen obstructing agent for the respiratory tract. The allergen obstructing agent comprises, by weight, 65 to 85% of white oil, 5 to 25% of Vaseline, 5 to 25% of paraffin and 5 to 25% of microcrystalline wax. A preparation method for the allergen obstructing agent comprises the following steps: mixing all the above-mentioned components; heating the obtained mixture to 60 to 120 DEG C and carrying out stirring at the same time; and carrying out cooling after full mixing so as to obtain the finished allergen obstructing agent. According to embodiments in the invention, the allergen obstructing agent can form a protection film with strong adhesion in the nasal cavity to obstruct immediate allergy induced by inhalation allergen and mitigates symptoms of inhalation allergy, thereby achieving a curative effect on prevention of immediate allergy.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a respiratory allergen blocker and a preparation method thereof. Background technique [0002] Allergic disease is one of the diseases with a relatively high incidence rate at present. About 20%-30% of the population has been or is troubled by this disease. Among allergic diseases, inhalation allergy is the most common, accounting for about 65% of allergic diseases, and the incidence of allergic diseases is increasing year by year, especially in developed countries such as Europe, America and Japan, where the incidence is higher than in developing countries. The main diseases caused by inhalation allergens are: allergic asthma, allergic rhinitis, allergic eczema, urticaria, allergic dermatitis, allergic conjunctivitis, etc. In inhalation allergic diseases, the cases caused by pollen, mites, fungi, animal fur, etc. are the most. [0003] Nasal allergen blockers currently on the ma...

Claims

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Application Information

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IPC IPC(8): A61K35/06A61P11/00
Inventor 方翔张纯
Owner 方翔
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